Research Progress of Banxia Xiexin Decoction in the Treatment of Chronic Gastritis
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v7i2.5333
Abstract
Banxia Xiexin decoction is a representative prescription of the acrid-opening and bitter-descending method, widely used for qi movement disorders and mixed coldheat patterns. Chronic gastritis is a common digestive inflammatory disease with high incidence and recurrence, seriously affecting patients’ quality of life. Banxia Xiexin decoction exerts favorable effects on chronic gastritis by inhibiting inflammatory factors, promoting gastric mucosal repair, and regulating intestinal flora. Clinically, it improves gastrointestinal hormone secretion and motility, alleviates inflammation, and reduces recurrence in HPrelated gastritis. This paper reviews the basic and clinical research progress of Banxia Xiexin decoction for chronic gastritis to provide reference for clinical treatment.
Keywords
Banxia Xiexin decoction; chronic gastritis; research progress; mechanism of action
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[1]Tang Xudong, Fang Jingyuan. Chinese Journal of Integrated Traditional Chinese and Western Medicine,2021,41(02):157-163. (in Chinese with English abstract)
[2]Zhao Jingyi, Zhao Luqing, Zhang Shengsheng. Zhang Shengsheng's experience in the treatment of chronic atrophic gastritis with low-grade intraepithelial neoplasia based on microsymptom accumulation [J]. Beijing Traditional Chinese Medicine, 2020, 39(1): 31-5.
[3]Gong Xinyang, Li Hepeng, Huang Chaoqun. Research progress of Banxia-Xiexin decoction in the treatment of Helicobacter pylori infection [J/OL]. Asia-pacific Traditional Medicine.2024.1-5.
[4]Chinese Society of Colorectal Cancer. Chinese expert consensus on multidisciplinary treatment of bone metastases from colorectal cancer (2020 edition)[J]. Chin J Cancer,2020,42(6):433-437.
[5]He Yumei, Tian Lei, Ma Aixia. Efficacy and safety of capecitabine plus irinotecan versus capecitabine plus oxaliplatin in the treatment of advanced/metastatic colorectal cancer: a systematic review [J]. Chin J Evidence-based Medicine,2019,19(3):302-309.
[6]ZhuY, HanY, BhandriNR, et al. CG121-031:Genomic Biomarker Testing,Trentments,and Survival Outcomes Among Patients with Ad·vanced or Matestatic NSCLC in the US:A Rtrospictive Cohort Study [J].Jnurnal of the National comprehensive Cancer Network:JNCCN,2021,19(5):1147-1150.
[7]LIU B B, Hu Y L, Lin M, et al. Study on the relationship between Helicobacter pylori infection and traditional Chinese medicine "damp-heat parasite" [J]. China Journal of Basic Medicine of Traditional Chinese Medicine,2019,25(8): 1094-1096.
[8]Chen Qiuping, Shao Mingyi, Fang Yuxuan, et al. Relationship between Helicobacter pylori infection and damp-heat parasites based on data mining [J]. Henan Traditional Chinese Medicine, 2021,42(10):1578-1581
[9]Tang Jiyin, Shan Zhaowei. Shan Z W J. Study on the treatment experience of Helicobacter pylori infection [J]. Hebei Journal of Traditional Chinese Medicine,2018,33(1):57-59. (in Chinese with English abstract)
[10]Zhang Yanbin, Guo Guangye, Zheng Caihua. Professor Guo Guangye's experience in treating Helicobacter pylori from "dampness, toxicity and deficiency" [J]. Sichuan Traditional Chinese Medicine,2023,41(5):1-5.
[11]Liang Min, Zhang Xingxing, Zhou Xiaohong. Zhou Xiaohong's experience in the treatment of Helicobacter pylori associated gastritis from spleen deficiency and dampness heat [J]. Jiangsu Traditional Chinese Medicine, 2012,54(6):22-25.
[12]Mengdi Jia, Lingfei Zhu, Shengsheng Zhang. Zhang Shengsheng's experience in the treatment of Helicobacter pylori gastritis with "detoxifying, restoring, leveling and protecting the membrane" [J]. Beijing Traditional Chinese Medicine,2023,42(8):863-865.
[13]Peng Xuejing, LIU Jie. Effects of Banxia-Xiexin decoction on PI3K /Akt/m TOR pathway in gastric mucosa of PLGC rats and its prevention and treatment [J]. Hunan Journal of Traditional Chinese Medicine, 2018, 34(10):155-7.
[14]Yang Xiang, Qiong Huang, Lin Yuan. Study on the mechanism of Rhizoma coptidis and Pinellia rhizoma in the treatment of chronic atrophic gastritis [J]. Natural Products Research and Development, 2022, 34(11):1822-31.
[15]Bai N, Yan G L, Liu W H, Guo S Y, Guo Y R, Tao Y [J]. Research progress on the pharmacological mechanism of traditional Chinese medicine for chronic atrophic gastritis based on JAK/STAT signaling pathway. Global Chinese Medicine (07),1406-1411.
[16]BRZOZOWA M, MIELAŃCZYK Ł, MICHALSKI M, et al. Role of Notch signaling pathway in gastric cancer pathogenesis [J]. Contemporary Oncology/Współczesna Onkologia, 2013, 17(1): 1-5.
[17]HUANG T, ZHOU Y, CHENG A S, et al. NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors? [J]. Molecular cancer, 2016, 15(1): 1-12.
[18]KELLY P N. Notch1 promotes cancer spread [J]. Science, 2017, 355(6331): 1278-9.
[19]YU B, YONGCAN C, YU C, et al. Efficacy of Banxia Xiexin decoction in a rat model of chronic atrophic gastritis [J]. Journal of Traditional Chinese Medicine, 2019, 39(06): 867.
[20]SUN X, XUE D, ZHANG K, et al. Acrid-release and bitter-downbearing therapy and banxia xiexin decoction regulate Wnt/β-catenin pathway, inhibit proliferation and invasion, and induce apoptosis in gastric cancer cells [J]. American Journal of Translational Research, 2021, 13(6): 6211.
[21]Elnozahi NA, Said EA, Bistawroos AE, et al. Effect of sodium butyrate on gastric ulcer aggravation and hepatic injury inflicted by bile duct ligation in rats[J]. SAUDI PHARM J, 2020, 28(6): 675-682.
[22]Shen F, Zhao CS, Shen MF, et al. The role of hydrogen sulfide in gastric mucosal damage[J]. Med Gas Res,2019, 9(2): 88-92.
[23]Xu Feixiang, Gong Zhenyu, Xue Mingming. Protective effect of Banxia-Xiexin decoction on acetic acid gastric ulcer in rats [J]. Chin J Clin Med, 2020,27(06):978-982.
[24]Lou Shuzhe, Li Qiang. Effects of Banxia-Xiexin Decoction on pathological morphology and vasomotor factors of gastric mucosa in rats with gastric ulcer [J]. Journal of Gansu University of Traditional Chinese Medicine,2018,35(6):12-15.
[25]Huang Y P, Zhan D F, Huang H, et al. Effects of Banxia-Xiexin Decoction human serum on TGF-β/Smad signaling pathway in GES-1 cells infected with HP [J]. Chinese Journal of Experimental Formulary,2018,24(14):91-96.
[26]Wang Jiang, Zhou Yongxue, Xie Yongbo. Effect of Banxia Xiexin Decoction on the expression of EGF and VEGF in gastric mucosa of rats with gastric ulcer and the significance of combination of cold and heat in the decoction [J]. Chin J Traditional Chinese Medicine,2015(11):2700-2702.
[27]Zhu Haiyan, Yang Fuquan, Zuo Qinchuan, Fang Zhiyan, Huang Lili, Huai Wenying, Wang Yanqiu, Zhang Tian'e. To explore the blood components of Banxia Xiexin Decoction and its mechanism in the treatment of ulcerative colitis of spleen deficiency based on UPLC-Q-Orbitrap HRMS combined with network pharmacology [J]. Natural Products Research and Development,1-27.
[28]CUI Shanshan, Gao Xiaoling, WU Yaosong, et al. Effects of Banxia-Xiexin Decoction on the morphology of gastric adenocarcinoma SGC-7901 cells and STAT3 pathway-related proteins [J]. Chinese Materia Medica Pharmacology & Clinic,2015,31(03):4-8.
[29]NIu Zhaoyuan, FENG Chong-lian, LIU Jia, et al. Feng Chong-lian's experience in the treatment of alcoholic liver disease [J]. Journal of Integrated Traditional Chinese and Western Medicine Hepatology,2020,30(6):555-558.
[30]Chao Yuanfang. Theory on the etiology and symptoms of various diseases: a new revised edition [M]. Beijing: People's Military Medical Press, 2006:229.
[31]The theory of warm heat [M]. Pan Jingjuan, dot proofing. Shanghai: Shanghai Second Military Medical University Press,2012.
[32]XU Zhengjin, Chen Jinchun, QIU Mingshan, et al. Zhu Liangchun's experience in the application of "Qingxie Method"[J]. Chin J Traditional Chinese Medicine,2011,26(7):1526-1528.
[33]WU Mengchao, LI Mengdong, YU Yanyan, et al. Practical Hepatology [M]. Beijing: People's Medical Publishing House,2011:234-235.
[34]Chen Y, Huang Y, Liu Y F, et al. Discussion on the treatment of alcoholic liver disease from the insidious pathogen theory [J]. Shizhen Traditional Chinese Medicine and Chinese Medicine,2015,26(7):1708-1710.
[35]Tang Xudong, Fang Jingyuan. Chinese Journal of Integrated Traditional Chinese and Western Medicine,2021,41(02):157-163. (in Chinese with English abstract)
[36]Ma Huimiao, Ma Minkai, Wu Liguo, et al. Effect of modified Banxia-Xiexin decoction on Helicobacter pylori associated gastritis and its effect on gastrointestinal hormones, oxidative stress and inflammatory state [J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2021,30(24):2681-2685.
[37]Liang H C, Chen W Y, Chen X Q. (24):2681-2685. (in Chinese with English abstract) Effect of modified Banxia-Xiexin decoction on Helicobacter pylori associated gastritis and analysis of its mechanism [J] Sichuan Traditional Chinese Medicine,2021,39 (1):86-89.
[38]Yang Wenjun, Wang Jing, Liu Erwei. Effect of modified Banxia-Xiexin decoction on gastric mucosal status, cytotoxin-associated protein A and vacuolating toxin A levels in patients with Helicobacter pylori associated gastritis (spleen-stomach damp-heat type) [J]. Hubei Journal of Traditional Chinese Medicine,2023,45(3):36-38.
[39]White snow peak, Huicai Xia. Effect of Banxia-Xiexin decoction combined with lansoprazole enteric-coated capsules on immune function and serum COX-2 in patients with chronic gastritis [J]. Chin J Med Med,2021,21(10):1721-1723.
[40]Peng Jing, Yang Yan. Effect of Banxia-Xiexin decoction on chronic gastritis with damp-heat accumulation and spleen syndrome [J]. Journal of Practical Chinese Medicine, 2012,38(02):198-199.
[41]Li Jingjing. Clinical observation of Banxia-Xiexin decoction in the treatment of chronic gastritis of spleen deficiency and stomach heat [J]. Guangming Traditional Chinese Medicine, 2012,37(02):206-209.
[42]Sun Hong-zhong, Ma Hong-mei. Effect of modified Banxia Xiexin decoction on the degree of hyperemia and edema in gastroscopic signs of patients with chronic gastritis [J]. Clinical Research of Chinese Medicine, 2012,14(05):59-61.
[43]Xie Jingqiu, Guo Min, Tang Min. Clinical study on Banxia-Xiexin Decoction in the treatment of chronic atrophic gastritis with spleen-stomach damp-heat type [J]. Clinical Research of Chinese Medicine, 2012,14(11):97-99.
[2]Zhao Jingyi, Zhao Luqing, Zhang Shengsheng. Zhang Shengsheng's experience in the treatment of chronic atrophic gastritis with low-grade intraepithelial neoplasia based on microsymptom accumulation [J]. Beijing Traditional Chinese Medicine, 2020, 39(1): 31-5.
[3]Gong Xinyang, Li Hepeng, Huang Chaoqun. Research progress of Banxia-Xiexin decoction in the treatment of Helicobacter pylori infection [J/OL]. Asia-pacific Traditional Medicine.2024.1-5.
[4]Chinese Society of Colorectal Cancer. Chinese expert consensus on multidisciplinary treatment of bone metastases from colorectal cancer (2020 edition)[J]. Chin J Cancer,2020,42(6):433-437.
[5]He Yumei, Tian Lei, Ma Aixia. Efficacy and safety of capecitabine plus irinotecan versus capecitabine plus oxaliplatin in the treatment of advanced/metastatic colorectal cancer: a systematic review [J]. Chin J Evidence-based Medicine,2019,19(3):302-309.
[6]ZhuY, HanY, BhandriNR, et al. CG121-031:Genomic Biomarker Testing,Trentments,and Survival Outcomes Among Patients with Ad·vanced or Matestatic NSCLC in the US:A Rtrospictive Cohort Study [J].Jnurnal of the National comprehensive Cancer Network:JNCCN,2021,19(5):1147-1150.
[7]LIU B B, Hu Y L, Lin M, et al. Study on the relationship between Helicobacter pylori infection and traditional Chinese medicine "damp-heat parasite" [J]. China Journal of Basic Medicine of Traditional Chinese Medicine,2019,25(8): 1094-1096.
[8]Chen Qiuping, Shao Mingyi, Fang Yuxuan, et al. Relationship between Helicobacter pylori infection and damp-heat parasites based on data mining [J]. Henan Traditional Chinese Medicine, 2021,42(10):1578-1581
[9]Tang Jiyin, Shan Zhaowei. Shan Z W J. Study on the treatment experience of Helicobacter pylori infection [J]. Hebei Journal of Traditional Chinese Medicine,2018,33(1):57-59. (in Chinese with English abstract)
[10]Zhang Yanbin, Guo Guangye, Zheng Caihua. Professor Guo Guangye's experience in treating Helicobacter pylori from "dampness, toxicity and deficiency" [J]. Sichuan Traditional Chinese Medicine,2023,41(5):1-5.
[11]Liang Min, Zhang Xingxing, Zhou Xiaohong. Zhou Xiaohong's experience in the treatment of Helicobacter pylori associated gastritis from spleen deficiency and dampness heat [J]. Jiangsu Traditional Chinese Medicine, 2012,54(6):22-25.
[12]Mengdi Jia, Lingfei Zhu, Shengsheng Zhang. Zhang Shengsheng's experience in the treatment of Helicobacter pylori gastritis with "detoxifying, restoring, leveling and protecting the membrane" [J]. Beijing Traditional Chinese Medicine,2023,42(8):863-865.
[13]Peng Xuejing, LIU Jie. Effects of Banxia-Xiexin decoction on PI3K /Akt/m TOR pathway in gastric mucosa of PLGC rats and its prevention and treatment [J]. Hunan Journal of Traditional Chinese Medicine, 2018, 34(10):155-7.
[14]Yang Xiang, Qiong Huang, Lin Yuan. Study on the mechanism of Rhizoma coptidis and Pinellia rhizoma in the treatment of chronic atrophic gastritis [J]. Natural Products Research and Development, 2022, 34(11):1822-31.
[15]Bai N, Yan G L, Liu W H, Guo S Y, Guo Y R, Tao Y [J]. Research progress on the pharmacological mechanism of traditional Chinese medicine for chronic atrophic gastritis based on JAK/STAT signaling pathway. Global Chinese Medicine (07),1406-1411.
[16]BRZOZOWA M, MIELAŃCZYK Ł, MICHALSKI M, et al. Role of Notch signaling pathway in gastric cancer pathogenesis [J]. Contemporary Oncology/Współczesna Onkologia, 2013, 17(1): 1-5.
[17]HUANG T, ZHOU Y, CHENG A S, et al. NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors? [J]. Molecular cancer, 2016, 15(1): 1-12.
[18]KELLY P N. Notch1 promotes cancer spread [J]. Science, 2017, 355(6331): 1278-9.
[19]YU B, YONGCAN C, YU C, et al. Efficacy of Banxia Xiexin decoction in a rat model of chronic atrophic gastritis [J]. Journal of Traditional Chinese Medicine, 2019, 39(06): 867.
[20]SUN X, XUE D, ZHANG K, et al. Acrid-release and bitter-downbearing therapy and banxia xiexin decoction regulate Wnt/β-catenin pathway, inhibit proliferation and invasion, and induce apoptosis in gastric cancer cells [J]. American Journal of Translational Research, 2021, 13(6): 6211.
[21]Elnozahi NA, Said EA, Bistawroos AE, et al. Effect of sodium butyrate on gastric ulcer aggravation and hepatic injury inflicted by bile duct ligation in rats[J]. SAUDI PHARM J, 2020, 28(6): 675-682.
[22]Shen F, Zhao CS, Shen MF, et al. The role of hydrogen sulfide in gastric mucosal damage[J]. Med Gas Res,2019, 9(2): 88-92.
[23]Xu Feixiang, Gong Zhenyu, Xue Mingming. Protective effect of Banxia-Xiexin decoction on acetic acid gastric ulcer in rats [J]. Chin J Clin Med, 2020,27(06):978-982.
[24]Lou Shuzhe, Li Qiang. Effects of Banxia-Xiexin Decoction on pathological morphology and vasomotor factors of gastric mucosa in rats with gastric ulcer [J]. Journal of Gansu University of Traditional Chinese Medicine,2018,35(6):12-15.
[25]Huang Y P, Zhan D F, Huang H, et al. Effects of Banxia-Xiexin Decoction human serum on TGF-β/Smad signaling pathway in GES-1 cells infected with HP [J]. Chinese Journal of Experimental Formulary,2018,24(14):91-96.
[26]Wang Jiang, Zhou Yongxue, Xie Yongbo. Effect of Banxia Xiexin Decoction on the expression of EGF and VEGF in gastric mucosa of rats with gastric ulcer and the significance of combination of cold and heat in the decoction [J]. Chin J Traditional Chinese Medicine,2015(11):2700-2702.
[27]Zhu Haiyan, Yang Fuquan, Zuo Qinchuan, Fang Zhiyan, Huang Lili, Huai Wenying, Wang Yanqiu, Zhang Tian'e. To explore the blood components of Banxia Xiexin Decoction and its mechanism in the treatment of ulcerative colitis of spleen deficiency based on UPLC-Q-Orbitrap HRMS combined with network pharmacology [J]. Natural Products Research and Development,1-27.
[28]CUI Shanshan, Gao Xiaoling, WU Yaosong, et al. Effects of Banxia-Xiexin Decoction on the morphology of gastric adenocarcinoma SGC-7901 cells and STAT3 pathway-related proteins [J]. Chinese Materia Medica Pharmacology & Clinic,2015,31(03):4-8.
[29]NIu Zhaoyuan, FENG Chong-lian, LIU Jia, et al. Feng Chong-lian's experience in the treatment of alcoholic liver disease [J]. Journal of Integrated Traditional Chinese and Western Medicine Hepatology,2020,30(6):555-558.
[30]Chao Yuanfang. Theory on the etiology and symptoms of various diseases: a new revised edition [M]. Beijing: People's Military Medical Press, 2006:229.
[31]The theory of warm heat [M]. Pan Jingjuan, dot proofing. Shanghai: Shanghai Second Military Medical University Press,2012.
[32]XU Zhengjin, Chen Jinchun, QIU Mingshan, et al. Zhu Liangchun's experience in the application of "Qingxie Method"[J]. Chin J Traditional Chinese Medicine,2011,26(7):1526-1528.
[33]WU Mengchao, LI Mengdong, YU Yanyan, et al. Practical Hepatology [M]. Beijing: People's Medical Publishing House,2011:234-235.
[34]Chen Y, Huang Y, Liu Y F, et al. Discussion on the treatment of alcoholic liver disease from the insidious pathogen theory [J]. Shizhen Traditional Chinese Medicine and Chinese Medicine,2015,26(7):1708-1710.
[35]Tang Xudong, Fang Jingyuan. Chinese Journal of Integrated Traditional Chinese and Western Medicine,2021,41(02):157-163. (in Chinese with English abstract)
[36]Ma Huimiao, Ma Minkai, Wu Liguo, et al. Effect of modified Banxia-Xiexin decoction on Helicobacter pylori associated gastritis and its effect on gastrointestinal hormones, oxidative stress and inflammatory state [J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2021,30(24):2681-2685.
[37]Liang H C, Chen W Y, Chen X Q. (24):2681-2685. (in Chinese with English abstract) Effect of modified Banxia-Xiexin decoction on Helicobacter pylori associated gastritis and analysis of its mechanism [J] Sichuan Traditional Chinese Medicine,2021,39 (1):86-89.
[38]Yang Wenjun, Wang Jing, Liu Erwei. Effect of modified Banxia-Xiexin decoction on gastric mucosal status, cytotoxin-associated protein A and vacuolating toxin A levels in patients with Helicobacter pylori associated gastritis (spleen-stomach damp-heat type) [J]. Hubei Journal of Traditional Chinese Medicine,2023,45(3):36-38.
[39]White snow peak, Huicai Xia. Effect of Banxia-Xiexin decoction combined with lansoprazole enteric-coated capsules on immune function and serum COX-2 in patients with chronic gastritis [J]. Chin J Med Med,2021,21(10):1721-1723.
[40]Peng Jing, Yang Yan. Effect of Banxia-Xiexin decoction on chronic gastritis with damp-heat accumulation and spleen syndrome [J]. Journal of Practical Chinese Medicine, 2012,38(02):198-199.
[41]Li Jingjing. Clinical observation of Banxia-Xiexin decoction in the treatment of chronic gastritis of spleen deficiency and stomach heat [J]. Guangming Traditional Chinese Medicine, 2012,37(02):206-209.
[42]Sun Hong-zhong, Ma Hong-mei. Effect of modified Banxia Xiexin decoction on the degree of hyperemia and edema in gastroscopic signs of patients with chronic gastritis [J]. Clinical Research of Chinese Medicine, 2012,14(05):59-61.
[43]Xie Jingqiu, Guo Min, Tang Min. Clinical study on Banxia-Xiexin Decoction in the treatment of chronic atrophic gastritis with spleen-stomach damp-heat type [J]. Clinical Research of Chinese Medicine, 2012,14(11):97-99.
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