Research Progress in Modified Gegen Qinlian Decoction for the Treatment of Ulcerative Colitis
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v7i2.5331
Abstract
Ulcerative colitis is a common chronic inflammatory bowel disease with insidious onset and recurrent episodes. Although Western medicine can maintain clinical remission, it still fails to meet patients' therapeutic expectations. Gegen Qinlian Decoction improves intestinal mucosal barrier function and attenuates systemic and tissue inflammatory responses with remarkable clinical efficacy. This article reviews the research progress of modified Gegen Qinlian Decoction in the treatment of ulcerative colitis, aiming to provide a theoretical basis for the clinical diagnosis and treatment of ulcerative colitis.
Keywords
Gegen Qinlian Decoction; traditional Chinese medicine; ulcerative colitis; research progress
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[2]Long TR, Li SC. Clinical observation of Jianpi Yiqi Formula in treating chronic ulcerative colitis in remission stage. Journal of Practical Traditional Chinese Medicine. 2021;(02):181-182.
[3]Shi R, Li JX, Shen H, Tang XD. Expert consensus on TCM diagnosis and treatment of ulcerative colitis (2023). China Journal of Traditional Chinese Medicine and Pharmacy. 2024;(01):288-296.
[4]Zeng PA. Clinical study on modified Shaoyao Decoction in treating ulcerative colitis (type of dampness-heat accumulation). [D]. Jiangxi University of Chinese Medicine; 2022.
[5]Qin SM, Zhang HY, Wu HM, Zheng H, Zhan K, Huang MY, Yang YM, Huang SG. Study on syndrome and syndrome element distribution characteristics of ulcerative colitis based on modern literature. Global Traditional Chinese Medicine. 2021;(03):389-394.
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[11]Huang XL, Jia XW, Ding YQ. Research progress in clinical application of Gegen Qinlian Decoction. Journal of Shandong University of Traditional Chinese Medicine. 2020;(02):215-220.
[12]Wu CM, Xie GZ, Zheng T, Tan ZJ, Hui HY. Research progress on application of Gegen Qinlian Decoction and its effect on intestinal barrier. Chinese Journal of Infection Control. 2023;(12):1540-1546.
[13]Li H, Li Y. Effect of Gegen Qinlian Decoction on TLR4/MyD88 signaling pathway in patients with ulcerative colitis of downward flow of dampness-heat type. Acta Chinese Medicine and Pharmacology. 2024;(04):71-75.
[14]Fu J. Systematic evaluation and meta-analysis of modified Gegen Qinlian Decoction in treating ulcerative colitis. [D]. Hubei University of Chinese Medicine; 2023.
[15]Zhao ML, Zheng J, Guo YT. Research progress of Gegen Qinlian Decoction and its modified prescription in treating ulcerative colitis. Chinese Journal of Experimental Traditional Medical Formulae. 2023;(20):239-246.
[16]Zhong Y, Yu Y. Therapeutic effect of Gegen Qinlian Decoction combined with mesalazine on ulcerative colitis and its influence on inflammatory factors. Medical Information. 2023;(16):141-143, 151.
[17]Zhao CL, Zhang LW, Yang YC. Retention enema with Gegen Qinlian Decoction plus Bletilla striata for acute attack of chronic ulcerative colitis: 30 cases. Guiding Journal of Traditional Chinese Medicine and Pharmacy. 2012;18(7):31-33.
[18]Wang ZM, Zhang FF. Clinical observation on 60 cases of ulcerative colitis treated with modified Gegen Qinlian Decoction retention enema. Jiangsu Journal of Traditional Chinese Medicine. 2014;(03):44-45.
[19]Li J, Wang SH, Zou XL, Hu CM, Yu YP, Jiang CM. Gegen Qinlian Decoction reduces TNF-α in ulcerative colitis. [Journal incomplete]. 2022;(12):1101-1105.
[20]Zheng CX, Feng JX, Chen ZT, Guo XH, Cheng NN, Dai X, Hu Y, Sun C. Protective mechanism of Gegen Qinlian Decoction on intestinal barrier in mice with ulcerative colitis. Chinese Journal of Veterinary Science. 2023;(03):571-576.
[21]Li YL, Liu JJ, Ma PG, Dong RJ, Ge DY, Liu HS, Peng GY, Li JX. Gegen Qinlian Decoction repairs intestinal mucosal epithelial barrier in ulcerative colitis mice by regulating MMP-9/p38 MAPK pathway. Chinese Journal of Experimental Traditional Medical Formulae. 2021;(04):8-15.
[22]Tatiya-Aphiradee N, Chatuphonprasert W, Jarukamjorn K. Immune response and inflammatory pathway of ulcerative colitis. Journal of Basic and Clinical Physiology and Pharmacology. 2018;30(1):1-10.
[23]Gao HT, Zhou WY, Wang JW, Hu GH, Pei JB. Research progress on Banxia Xiexin Decoction in treatment of ulcerative colitis. China Modern Doctor. 2023;(12):120-123.
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[25]Zhang N, Zhou XL, Liu S. Clinical efficacy of modified Gegen Qinlian Decoction combined with conventional therapy in patients with severe dampness-heat type ulcerative colitis. Chinese Traditional Patent Medicine. 2020;(02):351-355.
[26]Zhou CY, Dai YY, Wang BY, Yang LH. Research progress of Gegen Qinlian Decoction in treatment of ulcerative colitis. Journal of Liaoning University of Traditional Chinese Medicine. 2024;(04):179-184.
[27]Li ZY, Li LY, Zhang ZY, Qiu Y, Zhao F, Dai M, Chang Y. Effects of Gegen Qinlian Decoction combined with probiotics on intestinal flora and related inflammatory factors in mice with ulcerative colitis. Central South Pharmacy. 2024;(01):92-100.
[28]Fan YF, Gu JY. Clinical observation of modified Gegen Qinlian Decoction on mild to moderate ulcerative colitis and its influence on serum TNF-α, IL-10 and intestinal flora. Chinese Journal of Traditional Medical Science and Technology. 2024;(02):259-262.
[2]Long TR, Li SC. Clinical observation of Jianpi Yiqi Formula in treating chronic ulcerative colitis in remission stage. Journal of Practical Traditional Chinese Medicine. 2021;(02):181-182.
[3]Shi R, Li JX, Shen H, Tang XD. Expert consensus on TCM diagnosis and treatment of ulcerative colitis (2023). China Journal of Traditional Chinese Medicine and Pharmacy. 2024;(01):288-296.
[4]Zeng PA. Clinical study on modified Shaoyao Decoction in treating ulcerative colitis (type of dampness-heat accumulation). [D]. Jiangxi University of Chinese Medicine; 2022.
[5]Qin SM, Zhang HY, Wu HM, Zheng H, Zhan K, Huang MY, Yang YM, Huang SG. Study on syndrome and syndrome element distribution characteristics of ulcerative colitis based on modern literature. Global Traditional Chinese Medicine. 2021;(03):389-394.
[6]Xu YQ, Li ZJ, Zheng ML, Guan LY, Hu J, Tong CH, Zheng M. Clinical observation of Gegen Qinlian Decoction in treating ulcerative colitis. Guangming Journal of Chinese Medicine. 2024;(10):1911-1914.
[7]Gu WJ, editor. Treatise on Febrile Diseases. Beijing: China Medical Science Press; 1998.
[8]Chang MY. Rihua Zibu Bencao (Materia Medica of Rihua). Unpublished.
[9]Li ZZ. Bencao Tongxuan. Beijing: China Press of Traditional Chinese Medicine; 2015.
[10]Tao HJ, Shang ZJ. Mingyi Bie Lu (Miscellaneous Records of Famous Physicians). Beijing: People's Medical Publishing House; 1986.
[11]Huang XL, Jia XW, Ding YQ. Research progress in clinical application of Gegen Qinlian Decoction. Journal of Shandong University of Traditional Chinese Medicine. 2020;(02):215-220.
[12]Wu CM, Xie GZ, Zheng T, Tan ZJ, Hui HY. Research progress on application of Gegen Qinlian Decoction and its effect on intestinal barrier. Chinese Journal of Infection Control. 2023;(12):1540-1546.
[13]Li H, Li Y. Effect of Gegen Qinlian Decoction on TLR4/MyD88 signaling pathway in patients with ulcerative colitis of downward flow of dampness-heat type. Acta Chinese Medicine and Pharmacology. 2024;(04):71-75.
[14]Fu J. Systematic evaluation and meta-analysis of modified Gegen Qinlian Decoction in treating ulcerative colitis. [D]. Hubei University of Chinese Medicine; 2023.
[15]Zhao ML, Zheng J, Guo YT. Research progress of Gegen Qinlian Decoction and its modified prescription in treating ulcerative colitis. Chinese Journal of Experimental Traditional Medical Formulae. 2023;(20):239-246.
[16]Zhong Y, Yu Y. Therapeutic effect of Gegen Qinlian Decoction combined with mesalazine on ulcerative colitis and its influence on inflammatory factors. Medical Information. 2023;(16):141-143, 151.
[17]Zhao CL, Zhang LW, Yang YC. Retention enema with Gegen Qinlian Decoction plus Bletilla striata for acute attack of chronic ulcerative colitis: 30 cases. Guiding Journal of Traditional Chinese Medicine and Pharmacy. 2012;18(7):31-33.
[18]Wang ZM, Zhang FF. Clinical observation on 60 cases of ulcerative colitis treated with modified Gegen Qinlian Decoction retention enema. Jiangsu Journal of Traditional Chinese Medicine. 2014;(03):44-45.
[19]Li J, Wang SH, Zou XL, Hu CM, Yu YP, Jiang CM. Gegen Qinlian Decoction reduces TNF-α in ulcerative colitis. [Journal incomplete]. 2022;(12):1101-1105.
[20]Zheng CX, Feng JX, Chen ZT, Guo XH, Cheng NN, Dai X, Hu Y, Sun C. Protective mechanism of Gegen Qinlian Decoction on intestinal barrier in mice with ulcerative colitis. Chinese Journal of Veterinary Science. 2023;(03):571-576.
[21]Li YL, Liu JJ, Ma PG, Dong RJ, Ge DY, Liu HS, Peng GY, Li JX. Gegen Qinlian Decoction repairs intestinal mucosal epithelial barrier in ulcerative colitis mice by regulating MMP-9/p38 MAPK pathway. Chinese Journal of Experimental Traditional Medical Formulae. 2021;(04):8-15.
[22]Tatiya-Aphiradee N, Chatuphonprasert W, Jarukamjorn K. Immune response and inflammatory pathway of ulcerative colitis. Journal of Basic and Clinical Physiology and Pharmacology. 2018;30(1):1-10.
[23]Gao HT, Zhou WY, Wang JW, Hu GH, Pei JB. Research progress on Banxia Xiexin Decoction in treatment of ulcerative colitis. China Modern Doctor. 2023;(12):120-123.
[24]Hu YN, Tang JY, Zhu WH, Yu D, Xu WJ, Fang JT, Zha HR, Wang FY, Zhang W. Research progress on mechanism of Gegen Qinlian Decoction in treating ulcerative colitis by regulating cytokines. Chinese Archives of Traditional Chinese Medicine. 2024.
[25]Zhang N, Zhou XL, Liu S. Clinical efficacy of modified Gegen Qinlian Decoction combined with conventional therapy in patients with severe dampness-heat type ulcerative colitis. Chinese Traditional Patent Medicine. 2020;(02):351-355.
[26]Zhou CY, Dai YY, Wang BY, Yang LH. Research progress of Gegen Qinlian Decoction in treatment of ulcerative colitis. Journal of Liaoning University of Traditional Chinese Medicine. 2024;(04):179-184.
[27]Li ZY, Li LY, Zhang ZY, Qiu Y, Zhao F, Dai M, Chang Y. Effects of Gegen Qinlian Decoction combined with probiotics on intestinal flora and related inflammatory factors in mice with ulcerative colitis. Central South Pharmacy. 2024;(01):92-100.
[28]Fan YF, Gu JY. Clinical observation of modified Gegen Qinlian Decoction on mild to moderate ulcerative colitis and its influence on serum TNF-α, IL-10 and intestinal flora. Chinese Journal of Traditional Medical Science and Technology. 2024;(02):259-262.
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