Clinical Efficacy of Modified Duhuo Jisheng Decoction in Treating Knee Osteoarthritis and Its Effects on Clinical Symptoms and Joint Function
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v7i2.5330
Abstract
Objective To investigate the intervention effect of modified Duhuo Jisheng Decoction on knee osteoarthritis (KOA). Methods Eighty KOA patients were enrolled and randomly divided into two groups (40 cases each). The control group received oral glucosamine sulfate, while the observation group was additionally treated with modified Duhuo Jisheng Decoction. The treatment course lasted 12 weeks. Traditional Chinese medicine (TCM) syndrome scores, VAS, WOMAC scores, total effective rate, and adverse events were compared. Results The reduction in each score was significantly greater in the observation group than in the control group (P<0.05). The total effective rate in the observation group (92.50%) was higher than that in the control group (75.00%) (P<0.05). The incidence of adverse reactions in the observation group (5.00%) was lower than that in the control group (20.00%) (P<0.05). Conclusion Modified Duhuo Jisheng Decoction as an adjunctive treatment for KOA can effectively alleviate symptoms, promote joint function recovery, and has good safety.
Keywords
Duhuo Jisheng Decoction; knee osteoarthritis; clinical symptoms; joint function; safety
Full Text
PDF - Viewed/Downloaded: 6 TimesReferences
[1] Nguyen T H, Le T T, Nguyen Q D, et al. Traditional Vietnamese herbal medicine TD0015 in Knee Osteoarthritis: A Phase-II randomized controlled trial[J]. Journal of Herbal Medicine, 2025, 30: 100558.
[2] Chan K H, Ching J Y L, Chan K L, et al. Therapeutic effect of Duhuo Jisheng Decoction add-on Tui-na manipulation on osteoarthritis of knee: a randomized controlled trial[J]. Chinese Medicine, 2023, 18: 82.
[3] Wang F, Shi L, Zhang Y, et al. Integrated network and experimental pharmacology for deciphering the medicinal substances and multiple mechanisms of Duhuo Jisheng Decoction in osteoarthritis therapy[J]. Evidence-Based Complementary and Alternative Medicine, 2020, 2020: 7275057.
[4] Zhang W M, Wang S Q, Zhang R X, et al. Evidence of Chinese herbal medicine Duhuo Jisheng decoction for knee osteoarthritis: a systematic review of randomised clinical trials[J]. BMJ Open, 2016, 6(1): e008973.
[5] Zheng S W, Zhou B, Yang L, et al. System pharmacology analysis to decipher the effect and mechanism of active ingredients combination from Duhuo Jisheng decoction on osteoarthritis in rats[J]. Journal of Ethnopharmacology, 2023, 321: 116679.
[6] Wang Q, Tan Z Y, Zhuge H Y, et al. Study on the therapeutic effect and mechanism of Duhuo Jisheng Decoction on knee osteoarthritis based on TLR-4/NF-κB P65 signaling pathway[J]. Journal of Chinese Medicinal Materials, 2024, 47(6): 1524-1530.
[2] Chan K H, Ching J Y L, Chan K L, et al. Therapeutic effect of Duhuo Jisheng Decoction add-on Tui-na manipulation on osteoarthritis of knee: a randomized controlled trial[J]. Chinese Medicine, 2023, 18: 82.
[3] Wang F, Shi L, Zhang Y, et al. Integrated network and experimental pharmacology for deciphering the medicinal substances and multiple mechanisms of Duhuo Jisheng Decoction in osteoarthritis therapy[J]. Evidence-Based Complementary and Alternative Medicine, 2020, 2020: 7275057.
[4] Zhang W M, Wang S Q, Zhang R X, et al. Evidence of Chinese herbal medicine Duhuo Jisheng decoction for knee osteoarthritis: a systematic review of randomised clinical trials[J]. BMJ Open, 2016, 6(1): e008973.
[5] Zheng S W, Zhou B, Yang L, et al. System pharmacology analysis to decipher the effect and mechanism of active ingredients combination from Duhuo Jisheng decoction on osteoarthritis in rats[J]. Journal of Ethnopharmacology, 2023, 321: 116679.
[6] Wang Q, Tan Z Y, Zhuge H Y, et al. Study on the therapeutic effect and mechanism of Duhuo Jisheng Decoction on knee osteoarthritis based on TLR-4/NF-κB P65 signaling pathway[J]. Journal of Chinese Medicinal Materials, 2024, 47(6): 1524-1530.
Copyright © 2026 Zhensong Cao, Yingang Li
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License