Cognitive Enhancement in PSCI: a Retrospective Study on rTMS and HBO therapy
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i3.4436
Abstract
Post-stroke cognitive impairment (PSCI) severely impacts quality of life. Though repetitive transcranial magnetic stimulation (rTMS) and hyperbaric oxygen (HBO) have been researched for PSCI, their combined efficacy remains understudied. This study enrolled ninety-five stroke patients, and categorized them into control group, rTMS group, HBO group, and combined rTMS-HBO group, assessing cognitive function with the Mini-Mental State Examination (MMSE). The combined group demonstrated improvements in total score and domains (namely orientation, memory, attention-calculation, and language). Notably, hemorrhagic stroke patients in this group had better attention-calculation enhancement. Thus, combined rTMS-HBO effectively alleviates PSCI cognitive deficits, offering a new approach for clinical management.
Keywords
post-stroke cognitive impairment; repetitive transcranial magnetic stimulation; hyperbaric oxygen therapy; Mini-Mental State Examination
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[4] Dowling, N. M., Johnson, S., & Nadareishvili, Z. (2024). Poststroke Cognitive Impairment and the Risk of Recurrent Stroke and Mortality: Systematic Review and Meta‐Analysis. Journal of the American Heart Association, 13(18), e033807.
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[6] Gong, C., Hu, H., Peng, X.-M., Li, H., Xiao, L., Liu, Z., Zhong, Y.-B., Wang, M.-Y., & Luo, Y. (2023). Therapeutic effects of repetitive transcranial magnetic stimulation on cognitive impairment in stroke patients: A systematic review and meta-analysis. Frontiers in Human Neuroscience, 17, 1177594.
[7] Guzmán, D. E., Rengifo, C. F., Guzmán, J. D., & Garcia Cena, C. E. (2024). Virtual reality games for cognitive rehabilitation of older adults: A review of adaptive games, domains and techniques. Virtual Reality, 28(2), 92.
[8] Hadanny, A., Golan, H., Fishlev, G., Bechor, Y., Volkov, O., Suzin, G., Ben-Jacob, E., & Efrati, S. (2015). Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage. Restorative Neurology and Neuroscience, 33(4), 471～486.
[9] Haire, C. M., Vuong, V., Tremblay, L., Patterson, K. K., Chen, J. L., & Thaut, M. H. (2021). Effects of therapeutic instrumental music performance and motor imagery on chronic post-stroke cognition and affect: A randomized controlled trial. NeuroRehabilitation, 48(2), 195～208.
[10] Hasina, S. N., Ainiyah, N., Wardhini, A. D. N., & Wijayanti, L. (2022). Analysis between cognitive impairment with the level of disability post-stroke patients: A cross-sectional study. Bali Medical Journal, 11(2), 742～746.
[11] He, A., Wang, Z., Wu, X., Sun, W., Yang, K., Feng, W., Wang, Y., & Song, H. (2023). Incidence of post-stroke cognitive impairment in patients with first-ever ischemic stroke: A multicenter cross-sectional study in China. The Lancet Regional Health - Western Pacific, 33, 100687.
[12] Li, N., Wang, H., Liu, H., Zhu, L., Lyu, Z., Qiu, J., Zhao, T., Ren, H., Huang, L., Chen, S., Hu, X., & Zhou, L. (2023). The effects and mechanisms of acupuncture for post-stroke cognitive impairment: Progress and prospects. Frontiers in Neuroscience, 17, 1211044.
[13] Liu, Y., Zhong, Z., Chen, J., Kuo, H., Chen, X., Wang, P., Shi, M., Yang, M., Liu, B., & Liu, G. (2024). Brain activation patterns in patients with post-stroke cognitive impairment during working memory task: A functional near-infrared spectroscopy study. Frontiers in Neurology, 15, 1419128.
[14] Wang, Y., Wang, L., Ni, X., Jiang, M., & Zhao, L. (2024). Efficacy of repetitive transcranial magnetic stimulation with different application parameters for post-stroke cognitive impairment: A systematic review. Frontiers in Neuroscience, 18, 1309736.
Copyright © 2025 Wenye Hu, Yufeng Xi, Chengrui Xu, Rong Luo
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