Journal of Clinical Medicine Research

Objective: The aim is to investigate the effect of free bone flap suspension technique on postoperative IL-1β expression in rabbits and to evaluate its regulatory effect on postoperative inflammatory response. Methods: Thirty New Zealand white rabbits were selected and divided into the suspension group, the non-suspension group and the control group. The levels of IL-1β in peripheral blood, CRP and immunohistochemical AOD were detected on the 1st, 3rd and 7th days after surgery, respectively. Results: On the first day after surgery, the concentration of IL-1β in the suspension group was 2.86±0.40 ng/L, significantly lower than 4.92±0.55 ng/L in the non-suspension group (P<0.001); On the 7th day, the suspension group decreased to 1.45±0.29 ng/L, approaching the control group. Immunohistochemical AOD values showed 0.34±0.06 in the suspension group, significantly lower than 0.58±0.05 in the non-suspension group (P<0.001). White blood cell and CRP levels recovered more quickly in the suspension group after surgery. Conclusion: Free bone flap suspension can effectively reduce postoperative IL-1β expression and inflammatory response, and has good biological and clinical application prospects.