Journal of Clinical Medicine Research

This paper systematically investigates the therapeutic effects of Macau Shuyanning topical gel synthesized from extracts of Chinese medicinal herbs including Panax ginseng, Dendrobium officinale, Lycium barbarum, Cassia obtusifolia, Chrysanthemum morifolium, Ligusticum chuanxiong, Salvia miltiorrhiza, kudzu root, pearl, and Astragalus membranaceus on dry eyes, eye astringency, and blurred vision in middle-aged and elderly individuals. A randomized, double-blind, placebo-controlled clinical trial conducted in 2023 at the Affiliated Hospital of the Faculty of Medicine, Osaka City University, Japan confirmed that the compound gel exhibits excellent efficacy against dryness and astringency in the eyes of middle-aged and elderly subjects. After 3 months of use, the treatment group showed an effective rate of 89.5%, compared with 12.5% in the control group using a placebo gel. The difference in efficacy between the two groups was significant and statistically meaningful (P<0.05), with no adverse reactions observed in either group. Additionally, another randomized, double-blind, placebo-controlled clinical trial conducted in 2024 at the same institution confirmed the gel’s remarkable therapeutic effect on blurred vision in middle-aged and elderly individuals. After 1 month of use, the effective rate was 94.5% in the treatment group and 25% in the control group, with a statistically significant difference (P<0.05) and no adverse reactions in both groups. Conclusion: The topical gel synthesized from extracts of Panax ginseng, Dendrobium officinale, Lycium barbarum, Cassia obtusifolia, Chrysanthemum morifolium, Ligusticum chuanxiong, Salvia miltiorrhiza, kudzu root, pearl, and Astragalus membranaceus demonstrates significant therapeutic effects on dry eyes, eye astringency, and blurred vision in middle-aged and elderly individuals, with good safety, making it worthy of clinical promotion and application.