Evaluation of the Clinical Efficacy of Levothyroxine Combined with Irbesartan and Hydrochlorothiazide in the Treatment of Severe Heart Failure
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i3.4411
Abstract
Objective: To investigate the clinical efficacy of the combination of levothyroxine and irbesartan hydrochlorothiazide in the treatment of severe heart failure. Method: From February 2022 to May 2023, 66 patients with severe heart failure in our hospital were selected and randomly divided into a control group (treated with irbesartan and hydrochlorothiazide monotherapy) and a study group (treated with levothyroxine combined with irbesartan and hydrochlorothiazide) using a coin toss method. By comparing and analyzing the clinical efficacy indicators of two groups of patients, evaluate the differences in efficacy and application value of different treatment plans. Result: The overall therapeutic effect of the study group was significantly higher than that of the control group (P<0.05). The improvement level of key indicators of cardiac function in the study group was significantly higher than that in the control group (P<0.05). The levels of inflammatory factors and serological indicators in the research group were significantly improved compared to the control group (P<0.05). As for the occurrence of adverse reactions, no significant difference was observed between the two groups (P>0.05). Conclusion: The combined use of levothyroxine and irbesartan hydrochlorothiazide has shown significant therapeutic effects in the treatment of severe heart failure, indicating that this combination therapy has broad application prospects and promotion value in clinical practice.
Keywords
levothyroxine, irbesartan and hydrochlorothiazide, severe heart failure
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[3] Wang Dan, Li Weicheng The effect of ivabradine adjuvant conventional therapy on heart rate variability, plasma BNP, and serum miR-27b and miR-208 in patients with severe heart failure [J]. Clinical Medical Research and Practice, 2025, 10 (07): 70-73.
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[5] Li Caihong, Lei Ruixin, Lin Xiaoyang The effect of dual level non-invasive positive pressure ventilation combined with recombinant human brain natriuretic peptide in the treatment of severe heart failure and its impact on patient hemodynamics and mMRC score [J]. Clinical Medicine, 2025, 45 (01): 68-70.
[6] Luo Xinyao, Wan Dingyuan, Wang Ke, etc Explainable machine learning models predict short-term mortality in intensive care units for patients with heart failure complicated by acute kidney injury: a retrospective cohort study [J]. Journal of Sichuan University (Medical Edition), 2025, 56 (01): 183-190.
[7] Liu Jianping, Liu Na, Nie Zhenyun The effect of Xinmailong injection combined with spironolactone tablets on BNP levels, exercise endurance, and cardiac function in patients with severe heart failure [J]. Drug Evaluation, 2024, 21 (11): 1394-1397.
[8] Guo Mingkai, Zhang Donghong, Ma Liang, etc Clinical efficacy of dopamine combined with nitroprusside in the treatment of severe heart failure in elderly patients and its impact on CysC, Hcy, and BNP levels [J]. Clinical Medical Research and Practice, 2024, 9 (32): 55-58.
[9] Mai Jiejian, Huang Tong The effect of recombinant human brain natriuretic peptide in the treatment of severe coronary heart disease with heart failure and its impact on patients' cardiac function, inflammatory factors, and adverse reactions [J]. Journal of Modern Medicine and Health Research, 2024, 8 (21): 57-60.
[10] Xiong Xingjiang Connotation and Treatment Experience of Chest Bi Deficiency Syndrome and Ginseng Decoction Formula Syndrome Based on Severe Cases and Modern Pathophysiological Mechanisms in Treating Acute and Critical Illnesses such as Coronary Heart Disease, Wind Heart Disease, Heart Failure, Hypotension, and Pulmonary Hypertension. Chinese Journal of Traditional Chinese Medicine, 2025, 50 (06): 1706-1714.
[11] Shi Shuai, Li Xiuwen, Zhao Yiting, etc Analysis of risk factors for severe infections and adverse cardiovascular events in patients with chronic renal failure and uremia undergoing hemodialysis maintenance treatment [J]. Advances in Modern Biomedicine, 2024, 24 (14): 2666-2671.
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[13] Xie Hongming, Zheng Jiajia, Gong Yingying Observation of the Application Value and Improvement of Cardiac Function of Thyroxine Combined with Irbesartan and Hydrochlorothiazide in the Treatment of Severe Heart Failure [J]. Northern Pharmacy, 2024, 21 (06): 179-181.
[14] Feng Xiaokai, Gao Xueliang The effect of recombinant human brain natriuretic peptide combined with low molecular weight heparin calcium on PaO2 and CRP levels in patients with severe pulmonary heart disease and heart failure [J]. Journal of Shanxi Health Vocational College, 2024, 34 (02): 22-24.
[15] Xu Xiao, Xu Huajuan, Li Ming, etc Correlation analysis of TNIP1 gene single nucleotide polymorphism and its mRNA expression level with pulmonary infection in elderly patients with chronic heart failure [J]. Journal of Xinjiang Medical University, 2024, 47 (04): 538-541+547.
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