Phenotyping and Targeted Therapy Strategies for Severe Asthma in Children from the Perspective of Precision Medicine
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i3.4406
Abstract
Severe asthma in children poses significant challenges to clinical management, characterized by poor control, frequent exacerbations, and potential long-term impacts on lung development. The paradigm of precision medicine has revolutionized the understanding and treatment of asthma by emphasizing individualized care based on patient-specific phenotypes. This paper aims to summarize the current progress in phenotyping severe asthma in children and explore targeted therapy strategies under the framework of precision medicine.
Keywords
severe asthma; children; precision medicine; phenotyping; targeted therapy; biologics
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[1] Wenzel SE. Type 2 inflammation in asthma—defining the path to targeted therapy. N Engl J Med. 2019;380(10):958-970.
[2] Phipatanakul W, et al. Biomarkers in pediatric asthma: current applications and future directions. J Allergy Clin Immunol Pract. 2020;8(5):1503-1516.
[3] Douglass JA, et al. Genetic basis of severe asthma in children. J Allergy Clin Immunol. 2021;147(2):429-444.
[4] Haldar P, et al. Phenotyping severe asthma: a cluster analysis of patients in a tertiary care asthma clinic. Am J Respir Crit Care Med. 2008;178(3):218-224.
[5] Zhang L, et al. Obesity and asthma: mechanisms and clinical implications. J Allergy Clin Immunol. 2021;148(2):291-308.
[6] Pilette C, et al. Non-type 2 inflammation in severe asthma: mechanisms and therapeutic approaches. Lancet Respir Med. 2020;8(7):716-728.
[2] Phipatanakul W, et al. Biomarkers in pediatric asthma: current applications and future directions. J Allergy Clin Immunol Pract. 2020;8(5):1503-1516.
[3] Douglass JA, et al. Genetic basis of severe asthma in children. J Allergy Clin Immunol. 2021;147(2):429-444.
[4] Haldar P, et al. Phenotyping severe asthma: a cluster analysis of patients in a tertiary care asthma clinic. Am J Respir Crit Care Med. 2008;178(3):218-224.
[5] Zhang L, et al. Obesity and asthma: mechanisms and clinical implications. J Allergy Clin Immunol. 2021;148(2):291-308.
[6] Pilette C, et al. Non-type 2 inflammation in severe asthma: mechanisms and therapeutic approaches. Lancet Respir Med. 2020;8(7):716-728.
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