Effect of Systemic Inflammatory Response Index on Cardiovascular Disease Risk in Patients with Chronic Kidney Disease
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i1.3712
Abstract
Objective: To investigate the effect of systemic inflammatory response index on cardiovascular disease in patients with chronic kidney disease.Methods: In this prospective cohort study, 12417 patients with chronic kidney disease (CKD) with complete data and no previous history of cardiovascular disease who participated in the health examination for the first time in Kailuan Group from 2006 to 2007 were selected as the observation objects, with new-onset cardiovascular disease as the endpoint event, and followed up until the end of 2021. Patients were grouped according to the SIRI quartile, Kaplan-Meier method was used to calculate the cumulative incidence of cardiovascular diseases and subtypes in different groups, and multivariate Cox proportional risk regression model was used to analyze the impact of different groups on cardiovascular diseases.Result: A total of 12417 participants were included in the study, 75.8% of whom were male. The mean age of the subjects was 57.6±13.5 years. During the mean follow-up period of (11.81±3.84) years, The incidence densities of CVD in each group were 11.79/1000, 13.86/1000, 14.84/1000 and 16.73/1000, respectively. After adjusting for confounding factors such as age and sex, Cox regression analysis showed that compared with group Q1, the HR (95%CI) of CVD in groups Q2, Q3 and Q4 were 1.14 (1.00,1.30), 1.17 (1.03,1.33) and 1.25 (1.10,1.42), respectively, P < 0.05.Conclusion: SIRI is an independent risk factor for cardiovascular disease in patients with chronic kidney disease.
Keywords
Systemic inflammatory response index; Chronic kidney disease; Cardiovascular diseases; Cohort study
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[3]United States Renal Data System. 2020 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States (National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2020).
[4]Kadatane SP, Satariano M, Massey M, et al. The role of inflammation in CKD. Cells. 2023;12(12):1581.
[5]Akchurin OM, Kaskel F. Update on inflammation in chronic kidney disease.Blood Purif. （2015） 39（1-3）：84–92.
[6]Zhang Y, Xing Z, Zhou K, et al. The predictive role of systemic inflammation response index （SIRI） in the prognosis of stroke patients. Clin Interv Aging. 2021;16:1997-2007.
[7]Dziedzic EA, Gąsior JS, Tuzimek A, et al. Investigation of the associations of novel inflammatory biomarkers-systemic inflammatory index (SII) and systemic inflammatory response index (SIRI)-with the severity of coronary artery disease and acute coronary syndrome occurrence. Int J Mol Sci. 2022;23(17):9553.
[8]Huang YW, Zhang Y, Feng C, et al. Systemic inflammation response index as a clinical outcome evaluating tool and prognostic indicator for hospitalized stroke patients: a systematic review and meta-analysis. Eur J Med Res. 2023;28(1):474.
[9]Kong F, Huang J, Xu C, et al. System inflammation response index: a novel inflammatory indicator to predict all-cause and cardiovascular disease mortality in the obese population. Diabetol Metab Syndr. 2023;15(1):195.
[10]Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate [published correction appears in Ann Intern Med. 2011 Sep 20;155(6):408]. Ann Intern Med. 2009;150(9):604-612.
[11]Thygesen K, Alpert JS, Jaffe AS, et al. Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol. 2018 Oct 30;72(18):2231-2264.
[12]Swedberg K, Cleland J, Dargie H, et al. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (up-date 2005): the task force for the diagnosis and treatment of chronic heart failure of the European society of Cardiology. EurHeart J 2005;26(1 1):11 15e40.
[13]Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke. 1989 Oct;20(10):1407-3.
[14]Zhang Y, Liu F, Wang Y. Evidence of the prognostic value of pretreatment systemic inflammation response index in cancer patients: a pooled analysis of 19 cohort studies. Dis Markers. 2020;2020:8854267.
[15]Han K, Shi D, Yang L, et al. Prognostic value of systemic inflammatory response index in patients with acute coronary syndrome undergoing percutaneous coronary intervention[J]. Ann Med, 2022,54(1):1667-1677.
[16]Zhao S, Dong S, Qin Y, et al. Inflammation index siriis associated with increased all- cause and cardiovascular mortality among patients with hypertension[J].Front Cardiovasc Med, 2023,9:1066219.
[17]Wang C, Yuan Y, Zheng M, et al. Association of age of onset of hypertension with cardiovascular diseases and mortality. J Am Coll Cardiol 2020;75(23):2921e30.
[18]Magliano DJ, Sacre JW, Harding JL, et al.Young-onset type 2 diabetes mellitus - implications for morbidity and mortality. Nat Rev Endocrinol 2020; 16(6):321e31.
[19]Barreto DV, Barreto FC, Liabeuf S, et al.Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease. Kidney Int. (2010) 77:550–6.
[20]Ebert T, Neytchev O, Witasp A, et al.Inflammation and oxidative stress in chronic kidney disease and dialysis patients.Antioxidants Redox Signaling. (2021) 35:1426–48.
[21]Kadatane SP, Satariano M, Massey M, et al. The role of inflammation in CKD. Cells. (2023) 12(12):1581.
[22]Hirsch K, Nolley S, Ralph DD, et al.Circulating markers of inflammation and angiogenesis and clinical outcomes across subtypes of pulmonary arterial hypertension. J Heart Lung Transplant. (2023) 42:173–82.
[23]Núñez J, Miñana G, Bodí V, et al. Low lymphocyte count and cardiovascular diseases. Curr Med Chem. 2011;18(21):3226–33.
[24]Aziz MH, Sideras K, Aziz NA, et al. The Systemic-immune-inflammation Index Independently Predicts Survival and Recurrence in Resectable Pancreatic Cancer and its Prognostic Value Depends on Bilirubin Levels: A Retrospective Multicenter Cohort Study. Ann Surg. 2019;270(1):139-146.
[25]Kim JH, Lim S, Park KS, et al. Total and differential WBC counts are related with coronary artery atherosclerosis and increase the risk for cardiovascular disease in Koreans. PLoS ONE. 2017;12(7):e0180332.
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