Journal: Frontiers of Chinese Medicine Research DOI: 10.32629/fcmr.v8i3.21812
Abstract
不寐即失眠,是国内外常见的睡眠障碍疾病,包含但不限于下丘脑-垂体- 肾上腺轴过度激活中枢神经系统过度觉醒、神经递质失衡及昼夜节律紊乱等发病机 制。研究表明,竞争性内源RNA(ceRNA)与不寐的发生发展密切相关。本文着眼于竞争 性内源RNA在不寐中发病的机制及中医药治疗,发现中医药可调节ceRNA网络的表达, 进而调控下游分子以干预不寐。中医药通过多途径、多靶点干预该网络展现出独特 优势,但全面系统地研究ceRNA调控不寐的机制及临床研究仍需深入探索。
Keywords
不寐；竞争性内源RNA；微小RNA；中医药
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