Journal: Advances in Medicine and Engineering Interdisciplinary Research DOI: 10.32629/ameir.v4i3.5467
Abstract
The neurological and psychiatric manifestations in two patients who met clinical criteria of Behcet's disease are observed and described throughout several decades. The presence of recurrent oral and genital canker sores is illustrated with images. One of the patients developed thrombosis of the femoral vein, and erythema nodosus was present in both. The ophthalmological evaluation showed absence of uveitis in both patients, and blindness by adult monocular dystrophic maculopathy without signs of retinal vasculitis in the female. Laboratory tests on blood and cerebrospinal fluid evidenced lymphocytic pleocytosis. The patergia skin test was negative. Likewise, laboratory tests determined an absence of findings compatible with other autoimmune diseases. Throughout the evaluation period, the clinical manifestations were correlated with the findings from tomography and brain magnetic resonance magnetic. Similarly, recurrent myelitis and its correlation with the results of medular magnetic resonance imaging are explained. The evaluation and follow-up period through outpatient consultation and hospitalization was prolonged: the 73-year-old male patient, who started the disease at age 35, was followed-up for 34 years; and the 50-year-old female patient, fell ill at the age of 28 and was followed-up for 8 years. This process allowed the understanding of the different morbid factors that influenced the serious evolution of the clinical picture.
Keywords
Behcet's disease; neurological; psyquiatric and recurrent myelitis
Full Text
PDF - Viewed/Downloaded: 0 TimesReferences
[1] Fountain EM, Dhurandar A. Neuro-Behcet’s disease: An unusual cause of headache. J. Gen Intern Med. 2014;29:956-960.
[2] Siva A, Özdogan H, Yazici H. Headache, neuro-psychiatric and computerized tomography findings in Behçet's syndrome. En: Lehner T, Barnes CG, editors. Recent Advances in Behçet's Disease. London: Royal Society of Medicine Service; 1986. pp. 247-254.
[3] Kalra S, Silman A, Akman-Demir G, et al. Diagnosis and management of Neuro-Behçet's disease: international consensus recommendations. J Neurol. 2014; 261(9):1662-76. doi: 10.1007/s00415-013-7209-3.
[4] Talarico R, Palagini L, d´Ascanio A, Elefante E, Ferrari C, Stagnaro C, et al. Epidemiology and management of neuropsychiatric disorders in Behçet's syndrome. CNS Drugs. 2015; 29(3):189-96. doi: 10.1007/s40263-015-0228-0.
[5] Espinosa-Barberi G, Galván FJ, Rodriguez P, Viera D, Medina R. Estudio multimodal y diagnóstico diferencial de la distrofia macular viteliforme. Arch Soc Canar Oftal. 2019;30:103-108.
[6] Albakaye M, Zahlan S, Louhab N, Kissani N. Acute transverse mielitis revealing neurobehcet disease. Rev Neurol. 2014;170(2):144-146.
[7] Visaga M, Campos P, Bancalari E, Romero F, Hernández H, Berrocal A, et al. Neurobehcet pediátrico: Presentación de un caso y revisión de la literatura. Rev Med Hered. 1996; 7(4): 178-181. DOI: 10.20453/rmh.v7i4.513.
[8] Alzamora B, Martínez F. Enfermedad de Behcet: Estudio clínico y tratamiento en el Hospital Arzobispo Loayza. Rev Med Hered. 2001;12(2): 58-64. DOI: 10.20453/rmh.v12i2.668.
[9] Molina R, Huerta A, Alva C, et al. Enfermedad de Neuro-Behcet en Perú: reporte de un caso y revisión de la literatura. Medware. 2017; 17(5):e6978 doi: 10.5867/medwave.2017.05.6978.
[2] Siva A, Özdogan H, Yazici H. Headache, neuro-psychiatric and computerized tomography findings in Behçet's syndrome. En: Lehner T, Barnes CG, editors. Recent Advances in Behçet's Disease. London: Royal Society of Medicine Service; 1986. pp. 247-254.
[3] Kalra S, Silman A, Akman-Demir G, et al. Diagnosis and management of Neuro-Behçet's disease: international consensus recommendations. J Neurol. 2014; 261(9):1662-76. doi: 10.1007/s00415-013-7209-3.
[4] Talarico R, Palagini L, d´Ascanio A, Elefante E, Ferrari C, Stagnaro C, et al. Epidemiology and management of neuropsychiatric disorders in Behçet's syndrome. CNS Drugs. 2015; 29(3):189-96. doi: 10.1007/s40263-015-0228-0.
[5] Espinosa-Barberi G, Galván FJ, Rodriguez P, Viera D, Medina R. Estudio multimodal y diagnóstico diferencial de la distrofia macular viteliforme. Arch Soc Canar Oftal. 2019;30:103-108.
[6] Albakaye M, Zahlan S, Louhab N, Kissani N. Acute transverse mielitis revealing neurobehcet disease. Rev Neurol. 2014;170(2):144-146.
[7] Visaga M, Campos P, Bancalari E, Romero F, Hernández H, Berrocal A, et al. Neurobehcet pediátrico: Presentación de un caso y revisión de la literatura. Rev Med Hered. 1996; 7(4): 178-181. DOI: 10.20453/rmh.v7i4.513.
[8] Alzamora B, Martínez F. Enfermedad de Behcet: Estudio clínico y tratamiento en el Hospital Arzobispo Loayza. Rev Med Hered. 2001;12(2): 58-64. DOI: 10.20453/rmh.v12i2.668.
[9] Molina R, Huerta A, Alva C, et al. Enfermedad de Neuro-Behcet en Perú: reporte de un caso y revisión de la literatura. Medware. 2017; 17(5):e6978 doi: 10.5867/medwave.2017.05.6978.
Copyright © 2026 Marco A. Castañeda, César Durán Espinoza, Carlos Saúl Peña
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License