非侵入性生物标志物在炎症性肠病中的研究进展
Journal: Frontier Forum of Clinical Medicine DOI: 10.12238/ffcr.v3i5.16275
Abstract
炎症性肠病（Inflammatory bowel disease，IBD）是一种以慢性肠道炎症为特征的疾病，主要包括克罗恩病（CD）和溃疡性结肠炎（UC）。其发病机制尚未完全阐明，普遍认为是遗传易感个体在环境、微生物群、感染及免疫异常等多因素共同作用下所致。当前，内镜和病理学检查仍是疾病评估的主要手段，但因其具有侵入性、费用较高且体验较差，限制了患者的接受度。近年来，无创生物标志物的研究为IBD的病情评估与疗效监测提供了新途径。本文系统回顾了血液无创生物标志物及其他潜在生物标志物在IBD诊疗中的应用前景。通过将这些标志物与临床参数相结合，有望减少侵入性操作，推动个体化治疗，早期识别疾病活动与缓解状态，从而提升诊疗精准度，改善患者预后及生活质量。
Keywords
炎症性肠病；生物标志物；中性粒细胞
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[1] ZHOU Z， ZHANG Y， YANG X， et al Clinical signifi⁃ cance of novel neutrophil-based biomarkers in the diag nosis and prediction of response to infliximab therapy in Crohn's disease ［J］. Front Immunol， 2022， 13： 865968.
[2] FU W， FU H， YE W， et al Peripheral blood neutro⁃ phil-to-lymphocyte ratio in inflammatory bowel disease and disease activity： a meta-analysis［J］. Int Immuno⁃ pharmacol，2021，101（Pt B）：108235.
[3] SCHIEFFER K M， BRUFFY S M， RAUSCHER R， et al Reduced total serum bilirubin levels are associated with ulcerative colitis［J］. PLoS One，2017，12（6）： e0179267.
[4] LENÍČEK M， DURICOVÁ D， HRADSKY O， et al The relationship between serum bilirubin and Crohn's disease［J］. Inflamm Bowel Dis， 2014， 20（3） ： 481-487.
[5] CHEN Y H， WANG L， FENG S Y， et al The relation⁃ ship between C-reactive protein/albumin ratio and dis⁃ ease activity in patients with inflammatory bowel disease ［J］. Gastroenterol Res Pract，2020，2020：3467419.
[6] Xu M, Cen M, Chen X, et al. Correlation between Serological Biomarkers and Disease Activity in Patients with Inflammatory Bowel Disease[J. BioMed research international,2019, 2019: 6517549.
[7] Caviglia GP, Dughera F, Ribaldone DG, et al Serum zonulin in patients with inflammatory bowel disease: a pilot study. Minerva Med 2019; 110: 95-100.
[8] Wang J, Ortiz C, Fontenot L, et al. High circulating elafin levels are associated with Crohn’s disease-associated intestinal strictures. PLoS One 2020; 15: e0231796.
[2] FU W， FU H， YE W， et al Peripheral blood neutro⁃ phil-to-lymphocyte ratio in inflammatory bowel disease and disease activity： a meta-analysis［J］. Int Immuno⁃ pharmacol，2021，101（Pt B）：108235.
[3] SCHIEFFER K M， BRUFFY S M， RAUSCHER R， et al Reduced total serum bilirubin levels are associated with ulcerative colitis［J］. PLoS One，2017，12（6）： e0179267.
[4] LENÍČEK M， DURICOVÁ D， HRADSKY O， et al The relationship between serum bilirubin and Crohn's disease［J］. Inflamm Bowel Dis， 2014， 20（3） ： 481-487.
[5] CHEN Y H， WANG L， FENG S Y， et al The relation⁃ ship between C-reactive protein/albumin ratio and dis⁃ ease activity in patients with inflammatory bowel disease ［J］. Gastroenterol Res Pract，2020，2020：3467419.
[6] Xu M, Cen M, Chen X, et al. Correlation between Serological Biomarkers and Disease Activity in Patients with Inflammatory Bowel Disease[J. BioMed research international,2019, 2019: 6517549.
[7] Caviglia GP, Dughera F, Ribaldone DG, et al Serum zonulin in patients with inflammatory bowel disease: a pilot study. Minerva Med 2019; 110: 95-100.
[8] Wang J, Ortiz C, Fontenot L, et al. High circulating elafin levels are associated with Crohn’s disease-associated intestinal strictures. PLoS One 2020; 15: e0231796.
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