RASSF10蛋白在肿瘤中的作用及研究进展
Journal: Frontier Forum of Clinical Medicine DOI: 10.12238/ffcr.v3i4.15415
Abstract
RASSF10蛋白是Ras相关结构域家族（RASSF）最新被确认的成员，该蛋白是近年来被证实的一种新型肿瘤抑制蛋白。多项研究表明，RASSF10蛋白在多种肿瘤疾病及非肿瘤疾病中，主要通过调控多种关键的细胞内信号通路实现，从调控细胞周期及细胞的增殖、分化、迁移和凋亡、抑制上皮-间充质转化，到表观遗传修饰、微观稳定性调控、代谢调控、参与DNA损伤应答等多层次、多阶段、复杂的生物学过程，RASSF10发挥“信号枢纽”的作用，从而在抑制肿瘤的发生发展中有着不可替代的作用。因此，本综述系统梳理RASSF10在肿瘤领域的作用及研究进展，旨在为肿瘤的精准防治提供新的理论支撑和干预靶点。
Keywords
RASSF10蛋白；肿瘤；调控机制；信号通路
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[6] Liu Y, et al. RASSF10 re-sensitizes BRCA1-mutated TNBC to PARPi[J]. Nature Communications, 2022, 13(1):1254.
[7] Wang X, et al. "RASSF10 attenuates vascular calcification throughinhibiting BMP2-Smad1/5/8 signaling"[J]. Arteriosclerosis, Thrombosis,and Vascular Biology, 2021, 41(7):2209-2222.
[8] Liu Y, et al. "RASSF10 rescues synaptic dysfunction in Alzheimer's disease by stabilizing PSD-95"[J]. Nature Neuroscience, 2022, 25(4):512-525.
[9] Zhang R, et al. "Hepatocyte RASSF10 orchestrates hepatic gluconeogenesis via HIF-1α suppression"[J]. Cell Metabolism, 2023, 35(2):298-315.
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