种植体周围软组织增量的新策略：i-PRF、ADM 及微针的联 合应用
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i4.15541
Abstract
种植体周围软组织在维持长期稳定性及美学效果方面具有重要的临床意义。传统的自体软组织移植(如游离龈移植、上皮下结缔组织移植)虽被认为是“金标准”,但存在供区损伤、手术时间长及患者依从性低等缺陷。近年来,可注射富血小板纤维蛋白(i-PRF)、脱细胞真皮基质(ADM)以及微针技术(MN)被逐渐应用于种植体周软组织增量研究。i-PRF通过持续释放多种生长因子促进血管生成和组织修复；ADM作为三维胶原支架,可维持空间并增强黏膜厚度；微针则通过机械微创刺激诱导胶原沉积与血管新生,并为i-PRF的渗透提供通道。本文通过阐述i-PRF、ADM、MN各自的机制以及联合应用的优势,以期为未来的软组织增量提供一种新的思路。
Keywords
软组织增量；脱细胞真皮基质膜；可注射富血小板纤维蛋白；微针疗法
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[7] Zang J,Su L,Luan Q,Liu G,Li S,Yu X.Clinical and histolog ical evaluation of the use of acellular dermal matrix(ADM) membrane in peri-implant vertical soft tissue augmentation: A controlled clinical trial. Clin Oral Implants Res.2022 Jun;33(6):586-597.
[8] Aust M C,Reimers K,Repenning C, et al.Percutaneous col lagen induction therapy: An alternative treatment for burn scars[J].Burns,2010,36(6):836-843.
[9] Sidharthan A,Shetty S S,Thakur S,et al.Efficacy of inje ctable platelet-rich fibrin with microneedling for gingival phenotype modification: A randomized controlled clinical trial[J].J Periodontol,2024.
[10] Özsağır S,Öngöz Dede F,Ballı U,et al.Microneedling with injectable platelet-rich fibrin in gingival phenotype modification:A split-mouth randomized clinical study[J].J Oral Biol Craniofac Res,2023,13(5):748-754.
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[13] emmerman A,Cleeren G J,Castro A B,et al.L-PRF for inc reasing the width of keratinized mucosa around implants: a split-mouth, randomized, controlled pilot clinical trial[J]. Journal of Periodontal Research,2018,53(5):793-800.
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[15] Zhang,S.,Sheng,R.,Fan,Z.et al.Expert consensus on peri -implant keratinized mucosa augmentation at second-stage surgery.Int J Oral Sci 17,51(2025)
[16] Jamjoom AG.From Healing to Regeneration: A Comprehens ive Review of the Efficacy of Platelet-Rich Fibrin in Periodontal Plastic Surgery Procedures. Cureus.2024 Sep 12;16(9):e69287.
[17] K1z1ltoprak M,Uslu MÖ.Comparison of the effects of injectable platelet-rich fibrin and autologous fibrin glue applications on palatal wound healing:a randomized controlled clinical trial.Clinical Oral Investigations.2020.pp.4549-4561.
[18] Jasmine S,Thangavelu A,Janarthanan K,et al.Antimicro bial and antibiofilm potential of injectable platelet rich fibrin—A second-generation platelet concentrate—Against biofilm producing oral staphylococcus isolates[J].Saudi Jour nal of Biological Sciences,2020,27(1):41-46.
[19] Creighton RL,Faber KA,Tobos CI,Doan MA,Guo T,Woodrow KA. Oral mucosal vaccination using integrated fiber microne edles.J Control Release.2024 Mar;367:649-660.
[20] Ferreira L E N,Franz-Montan M, Benso B, et al. Micron eedles for oral mucosal delivery–Current trends and perspe ctive on future directions[J]. Expert opinion on drug delive ry,2023,20(9):1251-1265.
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