糖尿病足发生的影响因素及风险预测模型研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i4.15540
Abstract
糖尿病足是糖尿病患者最严重的慢性并发症之一,也是导致非创伤性截肢的主要原因。糖尿病足的发生不仅会带来疼痛、感染等躯体痛苦,也会引起焦虑、抑郁等不良情绪,严重影响患者的身心健康,降低生活质量。糖尿病足的发生是多种因素共同作用的结果,导致糖尿病足发生的影响因素很多,所以准确识别这些影响因素,甄别糖尿病足高危人群,对于指导临床干预,降低患者伤残率有着重大意义。风险预测模型是通过整合统计学方法、机器学习算法及领域专业知识,对个体或群体在未来特定时间段内发生特定健康事件的概率进行量化评估的工具,其能对疾病的发生、转归等情况进行预测。近年来,风险预测模型在糖尿病领域中的应用越来越多,并且也体现出了较高的应用价值。本文将在分析糖尿病足发生相关危险因素的基础上,汇总国内外关于糖尿病足发生的风险预测模型研究,旨在为临床早期预防和干预糖尿病足提供一定借鉴。
Keywords
糖尿病足；影响因素；风险预测模型
Funding
百色市科学研究与技术开发计划,百科20222916。
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[2] OGURTSOVA K,MORBACH S,HAASTERT B,et al.Cumulative long-term recurrence of diabetic foot ulcers in two cohorts from centres in Germany and the Czech Republic[J].Diabetes research and clinical practice,2021(172):172.
[3] 李大志,朱江,于清原,等.性别对重症糖尿病足血管病变腔内治疗效果的影响[J].中国临床医学,2023,30(01):44-48.
[4] 杨帆,徐子辉,赵玉,等.基于糖尿病专病数据库构建糖尿病足溃疡预测模型[J].中华糖尿病杂志,2025,17(07):824-829.
[5] 李友梅,王燕,曹相菊,等.2型糖尿病患者中发生2型糖尿病足的影响因素分析[J].中国当代医药,2025,32(2):59-62.
[6] 徐旭英.《中国糖尿病足防治指南2019》解读[J].中国临床医生杂志,2023,51(4):394-397.
[7] LIN Q.Risk factors of lower limb amputation in diabet ic foot[J].Chinese Journal of Primary Medicine and Pharmacy,2020,27:348-350.
[8] YASUDA K,MIYAKE K,HORIKAWA Y,et al.Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellit us.Nat Genet. 2008;40(9):1092-1097.
[9] BOUCHARD L,HIVERT M F,GUAY S P,et al.Placental Adipone ctin Gene DNA Methylation Levels Are Associated With Mothers' Blood Glucose Concentration[J].Diabetes,2012,61(5):1272-1280.
[10] 白玉,邹云霞,张晨霞,等.2型糖尿病患者并发足病及足溃疡加重危险因素分析[J].护士进修杂志,2019,34(20):1829-1834.
[11] 周旦阳,任昉,牟新,等.糖尿病足病流行病学危险因素和病情的相关性分析[J].实用糖尿病杂志,2010,6(02):42-44.
[12] 朴莲善,崔演,裴海成,等.长期吸烟与胰岛素抵抗的关系[J].中国糖尿病杂志,2006,(04):253-254.
[13] 汪秋实,韩翱瀚,曹烨,等.吸烟与糖代谢异常关系研究进展[J].中国公共卫生,2017,33(07):1132-1135.
[14] 何泱.性激素在糖尿病足患者的变化及其与预后的关系[D].上海交通大学,2015.
[15] TANKÓ LB,BRUUNJM,ALEXANDERSEN P,et al.Novel associa tions between bioavailable estradiol and adipokines in elder ly women with different phenotypes of obesity:implications for atherogenesis.Circulation.2004;110(15):2246-2252.
[16] 马芳婷.糖尿病高危足患者足底压力特征及其影响因素研究[D].广东:暨南大学,2020.
[17] 胡翠娟,陈晚霞,鲁蓉,等.探讨糖尿病周围神经病变(DPN)对足底压力的影响[J].糖尿病天地,2020,17(4):235.
[18] JAMES S, WROBEL,NANCY J,et al.Do clinical examination variables predict high plantar pressures in the diabetic foot? [J].J Am Podiatr Med Assoc,2003,93:0.
[19] 蒋娅.2型糖尿病患者自然步态下赤足足底压力特征分析及影响因素调查[D].南方医科大学,2013.
[20] 张蕊,郑黎强,潘国伟.疾病发病风险预测模型的应用与建立[J].中国卫生统计,2015,32(4):724-726.
[21] BOYKO E J,AHRONI J H,COHEN V,et al.Prediction of diab etic foot ulcer occurrence using commonly available clinical information:the seattle diabetic foot study[J].Diabetes Care, 2006,29(6):1202-1207.
[22] HEALD A,LUNT M,RUTTER M K,et a1.Developing a foot ul cer risk model:what is needed to do this in a real world Drimarv care setting?[J].Diabet Med,2019,36(11):1412-1416.
[23] LV J,LI R,YUAN L,et al. Development and validation of a risk prediction model for foot ulcers in diabetic patients [J].J Diabetes Res,2023,2023:1199885.
[24] 谢晓冉,徐蓉,张静,等.糖尿病足风险预测模型的构建与验证[J].护理学杂志,2022,37(11):9-14.
[25] JIANG MY, GAN F,GAN M,et al.Predicting the Risk of Diabetic Foot Ulcers From Diabetics With Dysmetabolism:A Retrospective Clinical Trial[J].Front Endocrinol(Lausanne),2022,13:929864.
[26] SHI L,WEI H,ZHANG T,et a1.A Dotent weighted risk mod el for evaluating the occurrence and severity of diabetic fOOt ulcers[J].Diabet01 Metab Svndr,2021,13(1):92．
[27] 曾荣豪,李丽敏,王伟佳.基于机器学习的2型糖尿病足预测模型研究[J].国际检验医学杂志,2023,44(S01):50-55.
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