急性胰腺炎发病机制的进展研究
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i4.15535
Abstract
急性胰腺炎(AP)是临床上常见的可危及生命的急腹症,它是影响腹部的所有疾病中最复杂和最具临床挑战性的疾病之一。在过去的几十年里,急性胰腺炎的发病率每年按约3%的比例逐步增加。约有20%的患者可从无菌性局部炎症,发展成高住院率、高病死率的重症急性胰腺炎(SAP),SAP病情多变,多数合并多脏器功能衰竭,治疗难度大。AP以胰蛋白酶原激活异常为主要发病机制,导致胰腺细胞破坏、胰腺自身消化,引起局部及全身炎症反应为主要特征的疾病。尽管胰蛋白酶原理论已经提出了一百多年,但对于AP的发病机制尚未完全了解。为了解AP发展的发病机制,已经进行了许多其他研究。该综述将对相关部分研究机制进行总结及讨论。
Keywords
急性胰腺炎；流行病学；诊断；分类；钙超载；自噬；损伤相关分子模式
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[1] Sureka,Binit et al.“Imaging lexicon for acute pancr eatitis:2012 Atlanta Classification revisited.”Gastroentero logy report vol.4,1(2016):16-23.
[2] 王兴鹏,李兆申,袁耀宗,等.中国急性胰腺炎诊治指南(2013年,上海)[J].临床肝胆病杂志,2013,29(09):656-660.
[3] 曹英恩,李F,孙ZX等.调控重症急性胰腺炎大鼠肺微血管内皮细胞微管稳定性:青衣汤是一种潜在的CDK5抑制剂[J].炎症研究杂志,2024,(17):2513-2530.
[4] Hong W, Pan J,Goyal H,Zippi M.Editorial:Acute pancreat itis infection: Epidemiology, prevention, clinical characteri stics, treatment, and prediction. Front Cell Infect Microbiol. 2023;13:1175195.Published 2023Mar 21.
[5] 曹锋,李非,赵玉沛.《中国急性胰腺炎诊治指南(2021)》解读[J].中国实用外科杂志,2021,41(07):758-761.
[6] Sureka B, Bansal K, Patidar Y, Arora A. Imaging lexicon for acute pancreatitis: 2012 Atlanta Classification revisit ed.Gastroenterol Rep (Oxf).2016;4(1):16-23.doi:10.1093/gastro /gov036
[7] Diszházi G,Magyar Zé,Lisztes E,etal.TRPM4links calcium signaling to membrane potential in pancreatic acinarcells [J].JBiolChem,2021,297(3):101015.
[8] Romac JM,Shahid RA,Swain SM,et al.Piezo1 is a mechan ically activated ion channel and mediates pressure induced pancreatitis[J].NatCommun,2018,9(1):1715.
[9] 侯文杰,王美堂.急性胰腺炎的细胞发病机制研究进展[J].临床急诊杂志,2023,24(5):266-271,276.
[10] Gukovskaya AS,Gukovsky I,Algül H,Habtezion A. Autoph agy, Inflammation, and Immune Dysfunction in the Pathogene sis of Pancreatitis.Gastroenterology. 2017;153(5):1212-1226.doi:10.1053/j.gastro.2017.08.071.
[11] Mareninova OA, Sendler M, Malla SR, et al. Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis:LAMP-2 deficient mice develop pancreatitis.Cell Mol Gastroenterol Hepatol.2015;1(6):678-694.
[12] Kang,R., Zhang,Q., Hou,W., Yan,Z., Chen,R., Bonaroti,J., etal.(2014b).Intracellular Hmgb1 inhibits inflammatory nucleos ome release and limits acute pancreatitis in mice. Gastroente rology146,1097-1107.doi:10.1053/j.gastro.2013.12.015.
[13] Yasuda T.Ueda T. Shinzeki M. Sawa H. Nakajima T. Tak eyama Y.et al.(2007).Increase of high-mobility group box chro mosomal protein 1 in blood and injured organs in experiment al severe acute pancreatitis.Pancreas34,487-488.
[14] Zhou X, Jin S, Pan J, Lin Q, Yang S, Ambe PC, Basharat Z,Zimmer V,Wang W and Hong W(2022)Damage associated molecular patterns and neutrophil extracellular traps in acute pancrea titis.Front.Cell.Infect.Microbiol.12:927193.
[2] 王兴鹏,李兆申,袁耀宗,等.中国急性胰腺炎诊治指南(2013年,上海)[J].临床肝胆病杂志,2013,29(09):656-660.
[3] 曹英恩,李F,孙ZX等.调控重症急性胰腺炎大鼠肺微血管内皮细胞微管稳定性:青衣汤是一种潜在的CDK5抑制剂[J].炎症研究杂志,2024,(17):2513-2530.
[4] Hong W, Pan J,Goyal H,Zippi M.Editorial:Acute pancreat itis infection: Epidemiology, prevention, clinical characteri stics, treatment, and prediction. Front Cell Infect Microbiol. 2023;13:1175195.Published 2023Mar 21.
[5] 曹锋,李非,赵玉沛.《中国急性胰腺炎诊治指南(2021)》解读[J].中国实用外科杂志,2021,41(07):758-761.
[6] Sureka B, Bansal K, Patidar Y, Arora A. Imaging lexicon for acute pancreatitis: 2012 Atlanta Classification revisit ed.Gastroenterol Rep (Oxf).2016;4(1):16-23.doi:10.1093/gastro /gov036
[7] Diszházi G,Magyar Zé,Lisztes E,etal.TRPM4links calcium signaling to membrane potential in pancreatic acinarcells [J].JBiolChem,2021,297(3):101015.
[8] Romac JM,Shahid RA,Swain SM,et al.Piezo1 is a mechan ically activated ion channel and mediates pressure induced pancreatitis[J].NatCommun,2018,9(1):1715.
[9] 侯文杰,王美堂.急性胰腺炎的细胞发病机制研究进展[J].临床急诊杂志,2023,24(5):266-271,276.
[10] Gukovskaya AS,Gukovsky I,Algül H,Habtezion A. Autoph agy, Inflammation, and Immune Dysfunction in the Pathogene sis of Pancreatitis.Gastroenterology. 2017;153(5):1212-1226.doi:10.1053/j.gastro.2017.08.071.
[11] Mareninova OA, Sendler M, Malla SR, et al. Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis:LAMP-2 deficient mice develop pancreatitis.Cell Mol Gastroenterol Hepatol.2015;1(6):678-694.
[12] Kang,R., Zhang,Q., Hou,W., Yan,Z., Chen,R., Bonaroti,J., etal.(2014b).Intracellular Hmgb1 inhibits inflammatory nucleos ome release and limits acute pancreatitis in mice. Gastroente rology146,1097-1107.doi:10.1053/j.gastro.2013.12.015.
[13] Yasuda T.Ueda T. Shinzeki M. Sawa H. Nakajima T. Tak eyama Y.et al.(2007).Increase of high-mobility group box chro mosomal protein 1 in blood and injured organs in experiment al severe acute pancreatitis.Pancreas34,487-488.
[14] Zhou X, Jin S, Pan J, Lin Q, Yang S, Ambe PC, Basharat Z,Zimmer V,Wang W and Hong W(2022)Damage associated molecular patterns and neutrophil extracellular traps in acute pancrea titis.Front.Cell.Infect.Microbiol.12:927193.
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