甘油三酯-葡萄糖指数与脓毒症相关性的研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i4.15501
Abstract
脓毒症(Sepsis)是一种在重症监护病房(Intensive Care Unit,ICU)中常见的临床综合症,是一种在全球范围内发病率和死亡率均较高的疾病。研究显示,脓毒症患者普遍存在胰岛素抵抗(Insulin resistance,IR)现象,甘油三酯-葡萄糖指数(Triglyceride-glucose Index,TyG指数)作为一种简单可靠的联合血脂和血糖的IR的替代指标,具有很大的潜在价值。近年来的循证医学证据显示,甘油三酯-葡萄糖指数(TyG指数)与脓毒症的发病机制及临床预后存在显著相关性。本文综述TyG指数与脓毒症相关性的研究进展,旨在早期识别脓毒症人群,为脓毒症的临床诊疗提供新的思路和方法。
Keywords
甘油三酯-葡萄糖指数；脓毒症；胰岛素抵抗；关联性分析
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[3] Weng L,Zeng X Y,Yin P,等.Sepsis-related mortality in China:a descriptive analysis[J].Intensive Care Medicine,2018, 44(7):1071-1080.
[4] Rivas A M,Nugent K.Hyperglycemia, Insulin, and Insulin Resistance in Sepsis[J].The American Journal of the Medical Sciences,2021,361(3):297-302.
[5] 苏志红,朱利勇,高祥,等.高胰岛素-正葡萄糖钳夹实验评价Roux-en-Y胃旁路术对2型糖尿病患者胰岛素抵抗的改善作用[J].中南大学学报(医学版),2021,46(6):609-614.
[6] Simental-Mendía L E,Rodríguez-Morán M, GuerreroRomero F.The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects[J].Metabolic Syndrome and Related Disorders, 2008,6(4):299-304.
[7] Guerrero-Romero F,Simental-Mendía L E,GonzálezOrtiz M,等.The product of triglycerides and glucose,a simple measure of insulin sensitivity.Comparison with the euglycem ic-hyperinsulinemic clamp[J].The Journal of Clinical Endocri nology and Metabolism, 2010,95(7):3347-3351.
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[9] 王淑婷,马晓丹,崔鹏辉,等.TyG指数与胰岛素抵抗、糖尿病肾脏病研究进展[J].齐齐哈尔医学院学报,2024,45(19):1877-1881.
[10] Mirr M, Skrypnik D,Bogdański P,等.Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome[J].Journal of Endocrinological Investigation,2021,44(12):2831-2843.
[11] Dang K,Wang X,Hu J,等.The association between triglyc eride-glucose index and its combination with obesity indicat ors and cardiovascular disease:NHANES 2003-2018[J].Cardiova scular Diabetology,2024,23(1):8.
[12] Chen T,Qian Y,Deng X.Triglyceride glucose index is a significant predictor of severe disturbance of consciousness and all-cause mortality in critical cerebrovascular disease patients[J].Cardiovascular Diabetology,2023,22(1):156.
[13] 闵行,甄东户,汤旭磊,等.中老年人群甘油三酯葡萄糖乘积指数与糖尿病发病风险相关性的前瞻性队列研究[J].中国糖尿病杂志,2023,31(2):81-86.
[14] 李光耀,韩菲.甘油三酯葡萄糖指数在急性胰腺炎评估中的应用价值[J].胃肠病学和肝病学杂志,2022,31(6):619-624.
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[19] Barichello T,Generoso J S,Singer M,等.Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review[J].Critical Care (London, England),2022,26(1):14.
[20] Zhang H, Wu T, Ren C,等.p53 promotes the expansion of regulatory T cells via DNMT3a-and TET2-mediated Foxp3 exp ression in sepsis[J].Burns & Trauma,2023,11:tkad021.
[21] Yeung S T,Ovando L J,Russo A J,等.CD169+ macrophage intrinsic IL-10 production regulates immune homeostasis dur ing sepsis[J].Cell Reports,2023,42(3):112171.
[22] 王小女,张静,王斌,等.阻断炎症因子转化生长因子-β改善细菌脓毒症T细胞增殖抑制的实验研究[J].中医临床研究,2024,16(22):64-66+72.
[23] Sygitowicz G,Sitkiewicz D.Molecular mechanisms of or gan damage in sepsis: an overview[J].The Brazilian Journal of Infectious Diseases:An Official Publication of the Brazili an Society of Infectious Diseases,2020,24(6):552-560.
[24] Zhou X,Liu C,Xu Z,等.Combining host immune response biomarkers and clinical scores for early prediction of sepsis in infection patients[J].Annals of Medicine,2024,56(1):2396569.
[25] Liang P,Yu F.Value of CRP,PCT,and NLR in Prediction of Severity and Prognosis of Patients With Bloodstream Infectio ns and Sepsis[J].Frontiers in Surgery,2022,9:857218.
[26] 王晓艳,史继静,李晓亮,等.脓毒症患者炎性因子和T淋巴细胞与病情严重程度和预后的关系[J].中华医院感染学杂志,2024,34(16):2439-2443.
[27] 梁旭,李国旗,张红玉,等.血乳酸､IL-6联合SOFA评分对脓毒症患者28d死亡风险的预测价值[J].暨南大学学报(自然科学与医学版),2024,45(1):43-50.
[28] Su Y,Li D,Deng S,等.Prognostic value of coagulation and fibrinolysis function indexes and NETs for sepsis patients[J]. American Journal of Translational Research,2023,15(6):4164-4171.
[29] 李宁宁,翟展艺,李春苗,等.血清降钙素原、磷评估老年慢性阻塞性肺疾病合并呼吸衰竭患者预后的价值[J].福建医科大学学报,2024,58(06):402-406.
[30] Lee S M,Jo Y H,Lee J H,等.ASSOCIATIONS OF THE SERUM ALBUMIN CONCENTRATION AND SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE AT DISCHARGE WITH 1-YEAR MORTALITY IN SEPSIS SURVIVORS: A RETROSPECTIVE COHORT STUDY[J]. Shock (Augusta,Ga.),2023,59(4):547-552.
[31] Wei Q,Zhao J,Wang H,等.Correlation Analysis of Blood Glucose Level with Inflammatory Response and Immune Indicat ors in Patients with Sepsis[J].Disease Markers,2022,2022:8779 061.
[32] Turpin C,Catan A,Guerin-Dubourg A,等.Enhanced oxida tive stress and damage in glycated erythrocytes[J].PloS One,2020,15(7):e0235335.
[33] Saitoh S,Van Wijk K,Nakajima O.Crosstalk between Meta bolic Disorders and Immune Cells[J].International Journal of Molecular Sciences,2021,22(18):10017.
[34] Minjares M,Wu W,Wang J M.Oxidative Stress and MicroR NAs in Endothelial Cells under Metabolic Disorders[J].Cells, 2023,12(9):1341.
[35] Fang Y,Xiong B,Shang X,等.Triglyceride-glucose index predicts sepsis-associated acute kidney injury and length of stay in sepsis:A MIMIC-IV cohort study[J].Heliyon,2024,10(7): e29257.
[36] Lv Z,Wang J,Gu M,等.Association between the triglycer ide glucose index and short-term mortality in septic patients with or without obesity: a retrospective cohort study[J].Adip ocyte,2024,13(1):2379867.
[37] Cao Y,He L,Su Y,等.Triglyceride-glucose index and cli sepsis: A retrospective cohort study of MIM IC-IV[J].Journal of Cellular and Molecular Medicine,2024,28(16):70007.
[38] 刘成,周克兵,阳学风,等.TyG指数在脓毒症患者预后评估中的价值[J].实用休克杂志(中英文),2022,6(3):159-163.
[2] Rudd K E,Johnson S C,Agesa K M,等.Global, regional, and national sepsis incidence and mortality, 1990-2017:analysis for the Global Burden of Disease Study[J].Lancet (London,En gland),2020,395(10219):200-211.
[3] Weng L,Zeng X Y,Yin P,等.Sepsis-related mortality in China:a descriptive analysis[J].Intensive Care Medicine,2018, 44(7):1071-1080.
[4] Rivas A M,Nugent K.Hyperglycemia, Insulin, and Insulin Resistance in Sepsis[J].The American Journal of the Medical Sciences,2021,361(3):297-302.
[5] 苏志红,朱利勇,高祥,等.高胰岛素-正葡萄糖钳夹实验评价Roux-en-Y胃旁路术对2型糖尿病患者胰岛素抵抗的改善作用[J].中南大学学报(医学版),2021,46(6):609-614.
[6] Simental-Mendía L E,Rodríguez-Morán M, GuerreroRomero F.The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects[J].Metabolic Syndrome and Related Disorders, 2008,6(4):299-304.
[7] Guerrero-Romero F,Simental-Mendía L E,GonzálezOrtiz M,等.The product of triglycerides and glucose,a simple measure of insulin sensitivity.Comparison with the euglycem ic-hyperinsulinemic clamp[J].The Journal of Clinical Endocri nology and Metabolism, 2010,95(7):3347-3351.
[8] 刘亚琴,陈琰,马璐瑶,等.胰岛素抵抗新机制的研究进展[J].中国医药导报,2023,20(36):50-53+57.
[9] 王淑婷,马晓丹,崔鹏辉,等.TyG指数与胰岛素抵抗、糖尿病肾脏病研究进展[J].齐齐哈尔医学院学报,2024,45(19):1877-1881.
[10] Mirr M, Skrypnik D,Bogdański P,等.Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome[J].Journal of Endocrinological Investigation,2021,44(12):2831-2843.
[11] Dang K,Wang X,Hu J,等.The association between triglyc eride-glucose index and its combination with obesity indicat ors and cardiovascular disease:NHANES 2003-2018[J].Cardiova scular Diabetology,2024,23(1):8.
[12] Chen T,Qian Y,Deng X.Triglyceride glucose index is a significant predictor of severe disturbance of consciousness and all-cause mortality in critical cerebrovascular disease patients[J].Cardiovascular Diabetology,2023,22(1):156.
[13] 闵行,甄东户,汤旭磊,等.中老年人群甘油三酯葡萄糖乘积指数与糖尿病发病风险相关性的前瞻性队列研究[J].中国糖尿病杂志,2023,31(2):81-86.
[14] 李光耀,韩菲.甘油三酯葡萄糖指数在急性胰腺炎评估中的应用价值[J].胃肠病学和肝病学杂志,2022,31(6):619-624.
[15] Singer M,Deutschman C S,Seymour C W,等.The Third Int ernational Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)[J].JAMA,2016,315(8):801-810.
[16] Evans L, Rhodes A,Alhazzani W,等.Surviving sepsis cam paign: international guidelines for management of sepsis and septic shock 2021[J].Intensive Care Medicine, 2021,47(11): 1181-1247.
[17] Bauer M, Gerlach H, Vogelmann T,等.Mortality in sep sis and septic shock in Europe, North America and Australia between 2009 and 2019-results from a systematic review and meta-analysis[J].Critical Care (London, England),2020,24(1):239.
[18] 周峰,薛淑祯,赵国桢,等.中医药治疗脓毒症临床试验结局指标分析[J].天津中医药,2024,41(03):323-331.
[19] Barichello T,Generoso J S,Singer M,等.Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review[J].Critical Care (London, England),2022,26(1):14.
[20] Zhang H, Wu T, Ren C,等.p53 promotes the expansion of regulatory T cells via DNMT3a-and TET2-mediated Foxp3 exp ression in sepsis[J].Burns & Trauma,2023,11:tkad021.
[21] Yeung S T,Ovando L J,Russo A J,等.CD169+ macrophage intrinsic IL-10 production regulates immune homeostasis dur ing sepsis[J].Cell Reports,2023,42(3):112171.
[22] 王小女,张静,王斌,等.阻断炎症因子转化生长因子-β改善细菌脓毒症T细胞增殖抑制的实验研究[J].中医临床研究,2024,16(22):64-66+72.
[23] Sygitowicz G,Sitkiewicz D.Molecular mechanisms of or gan damage in sepsis: an overview[J].The Brazilian Journal of Infectious Diseases:An Official Publication of the Brazili an Society of Infectious Diseases,2020,24(6):552-560.
[24] Zhou X,Liu C,Xu Z,等.Combining host immune response biomarkers and clinical scores for early prediction of sepsis in infection patients[J].Annals of Medicine,2024,56(1):2396569.
[25] Liang P,Yu F.Value of CRP,PCT,and NLR in Prediction of Severity and Prognosis of Patients With Bloodstream Infectio ns and Sepsis[J].Frontiers in Surgery,2022,9:857218.
[26] 王晓艳,史继静,李晓亮,等.脓毒症患者炎性因子和T淋巴细胞与病情严重程度和预后的关系[J].中华医院感染学杂志,2024,34(16):2439-2443.
[27] 梁旭,李国旗,张红玉,等.血乳酸､IL-6联合SOFA评分对脓毒症患者28d死亡风险的预测价值[J].暨南大学学报(自然科学与医学版),2024,45(1):43-50.
[28] Su Y,Li D,Deng S,等.Prognostic value of coagulation and fibrinolysis function indexes and NETs for sepsis patients[J]. American Journal of Translational Research,2023,15(6):4164-4171.
[29] 李宁宁,翟展艺,李春苗,等.血清降钙素原、磷评估老年慢性阻塞性肺疾病合并呼吸衰竭患者预后的价值[J].福建医科大学学报,2024,58(06):402-406.
[30] Lee S M,Jo Y H,Lee J H,等.ASSOCIATIONS OF THE SERUM ALBUMIN CONCENTRATION AND SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE AT DISCHARGE WITH 1-YEAR MORTALITY IN SEPSIS SURVIVORS: A RETROSPECTIVE COHORT STUDY[J]. Shock (Augusta,Ga.),2023,59(4):547-552.
[31] Wei Q,Zhao J,Wang H,等.Correlation Analysis of Blood Glucose Level with Inflammatory Response and Immune Indicat ors in Patients with Sepsis[J].Disease Markers,2022,2022:8779 061.
[32] Turpin C,Catan A,Guerin-Dubourg A,等.Enhanced oxida tive stress and damage in glycated erythrocytes[J].PloS One,2020,15(7):e0235335.
[33] Saitoh S,Van Wijk K,Nakajima O.Crosstalk between Meta bolic Disorders and Immune Cells[J].International Journal of Molecular Sciences,2021,22(18):10017.
[34] Minjares M,Wu W,Wang J M.Oxidative Stress and MicroR NAs in Endothelial Cells under Metabolic Disorders[J].Cells, 2023,12(9):1341.
[35] Fang Y,Xiong B,Shang X,等.Triglyceride-glucose index predicts sepsis-associated acute kidney injury and length of stay in sepsis:A MIMIC-IV cohort study[J].Heliyon,2024,10(7): e29257.
[36] Lv Z,Wang J,Gu M,等.Association between the triglycer ide glucose index and short-term mortality in septic patients with or without obesity: a retrospective cohort study[J].Adip ocyte,2024,13(1):2379867.
[37] Cao Y,He L,Su Y,等.Triglyceride-glucose index and cli sepsis: A retrospective cohort study of MIM IC-IV[J].Journal of Cellular and Molecular Medicine,2024,28(16):70007.
[38] 刘成,周克兵,阳学风,等.TyG指数在脓毒症患者预后评估中的价值[J].实用休克杂志(中英文),2022,6(3):159-163.
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