槐耳清膏对 TNF-ɑ/IFN-γ诱导的 HaCaT 特应性皮炎细胞 模型的抗炎机制研究
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i3.14482
Abstract
目的：本研究旨在探讨槐耳清膏对TNF-ɑ/IFN-γ诱导的HaCat细胞特应性皮炎模型的抗炎机制。方法：采用实时荧光定量聚合酶链式反应检测TNF-ɑ/IFN-γ诱导后HaCaT细胞中趋化因子TARC、MDC的mRNA的表达。结论：槐耳清膏可通过抑制趋化因子TARC和MDC的生成,进而缓解特应性皮炎的炎症反应。
Keywords
特应性皮炎；槐耳清膏；趋化因子
Full Text
PDF - Viewed/Downloaded: 0 TimesReferences
[1] 张书琳.槐耳及其复方制剂槐杞黄颗粒的研究进展[J].医学综述,2015,21(1):114-6.
[2] 庄毅.抗癌新药槐耳冲剂的研究[J].中国药学杂志,1998,(5):273.
[3] WANG L,YU Z,WEI C,et al.Huaier aqueous extract protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NLRP3 inflammasome activation[J].Oncot arget,2017,8(20):32937-45.
[4] 孙雯,俞建,时毓民,等.中药槐耳调节哮喘缓解期儿童外周血单个核细胞Th1/Th2平衡的基因及蛋白水平研究[J].中华中医药杂志,2009,24(7):915-7.
[5] 关淇真,段昕所.槐耳清膏对TNF-ɑ/IFN-γ诱导的HaCaT特应性皮炎细胞模型的保护作用及机制研究[J].亚洲临床医学杂志,2024,7(12).
[6] FUJISAWA T, FUJISAWA R, KATO Y, et al. Presence of high contents of thymus and activation-regulated chemokine in pla telets and elevated plasma levels of thymus and activationregulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis [J].The Journal of allergy and clinical immunology,2002,110(1):139-46.
[7] RENERT-YUVAL Y,THYSSEN J P,BISSONNETTE R,et al.Bioma rkers in atopic dermatitis-a review on behalf of the Internati onal Eczema Council[J].The Journal of allergy and clinical immunology,2021,147(4):1174-90.e1.
[8] LEE K S,CHUN S Y,LEE M G,et al.The prevention of TNF- α/IFN-γ mixture-induced inflammation in human keratinoc yte and atopic dermatitis-like skin lesions in Nc/Nga mice by mineral-balanced deep sea water[J].Biomedicine & pharmacoth erapy=Biomedecine & pharmacotherapie,2018,97:1331-40.
[9] PARK J H, AHN E K,KO H J, et al. Korean red ginseng water extract alleviates atopic dermatitis-like inflammatory respo nses by negative regulation of mitogen-activated protein kinase signaling pathway in vivo[J].Biomedicine & pharmacoth erapy=Biomedecine & pharmacotherapie,2019,117:109066.
[10] LEE J O,JANG Y, PARK A Y, et al. Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ- Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model[J].Journal of microbiology and biotechnology,2024,34(10):1969-80.
[2] 庄毅.抗癌新药槐耳冲剂的研究[J].中国药学杂志,1998,(5):273.
[3] WANG L,YU Z,WEI C,et al.Huaier aqueous extract protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NLRP3 inflammasome activation[J].Oncot arget,2017,8(20):32937-45.
[4] 孙雯,俞建,时毓民,等.中药槐耳调节哮喘缓解期儿童外周血单个核细胞Th1/Th2平衡的基因及蛋白水平研究[J].中华中医药杂志,2009,24(7):915-7.
[5] 关淇真,段昕所.槐耳清膏对TNF-ɑ/IFN-γ诱导的HaCaT特应性皮炎细胞模型的保护作用及机制研究[J].亚洲临床医学杂志,2024,7(12).
[6] FUJISAWA T, FUJISAWA R, KATO Y, et al. Presence of high contents of thymus and activation-regulated chemokine in pla telets and elevated plasma levels of thymus and activationregulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis [J].The Journal of allergy and clinical immunology,2002,110(1):139-46.
[7] RENERT-YUVAL Y,THYSSEN J P,BISSONNETTE R,et al.Bioma rkers in atopic dermatitis-a review on behalf of the Internati onal Eczema Council[J].The Journal of allergy and clinical immunology,2021,147(4):1174-90.e1.
[8] LEE K S,CHUN S Y,LEE M G,et al.The prevention of TNF- α/IFN-γ mixture-induced inflammation in human keratinoc yte and atopic dermatitis-like skin lesions in Nc/Nga mice by mineral-balanced deep sea water[J].Biomedicine & pharmacoth erapy=Biomedecine & pharmacotherapie,2018,97:1331-40.
[9] PARK J H, AHN E K,KO H J, et al. Korean red ginseng water extract alleviates atopic dermatitis-like inflammatory respo nses by negative regulation of mitogen-activated protein kinase signaling pathway in vivo[J].Biomedicine & pharmacoth erapy=Biomedecine & pharmacotherapie,2019,117:109066.
[10] LEE J O,JANG Y, PARK A Y, et al. Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ- Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model[J].Journal of microbiology and biotechnology,2024,34(10):1969-80.
Copyright © 2025 关淇真, 段昕所
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License