rTMS 对脑卒中患者疼痛感知功能的影响
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i3.14420
Abstract
脑卒中是全球发病率、致残率和死亡率较高的疾病之一。随着全球人口老龄化趋势的加剧,脑卒中已成为影响人类健康和生活质量的重大公共卫生问题之一。尽管医疗技术的进步使得脑卒中患者的生存率显著提高,大多数卒中患者的运动和感觉功能可以得到不同程度的恢复,但是,一些患者在卒中后仍然遭受身体受累侧的持续疼痛。这种疼痛发生在卒中后,与受损区域相关,称为中枢性卒中后疼痛(CPSP)。本文将从CPSP的特点和病因、rTMS治疗CPSP的疗效和证据、影响因素以及安全性与局限性三个方面,就当前rTMS对CPSP的治疗进展进行综述。
Keywords
脑卒中；中枢性卒中后疼痛(CPSP)；重复经颅磁刺激(rTMS)；疼痛感知
Full Text
PDF - Viewed/Downloaded: 0 TimesReferences
[1] Radiansyah, R.S.,and Hadi,D.W.(2023).Repetitive transc ranial magnetic stimulation in central post-stroke pain:curre nt status and future perspective.Korean J.Pain36,408-424.
[2] Dub,é, J.A.,and Mercier,C.(2011).Effect of pain and pain expectation on primary motor cortex excitability. Clin. Neurophysiol.122,2318-2323.
[3] Kumar, B.(2009).Central poststroke pain: a review of pathophysiology and treatment.Anesth.Analg.108,1645-1657.
[4] Scuteri,D.,Mantovani,E.,Tamburin,S.,Sandrini,G.,Corasaniti, M. T.,Bagetta, G.,et al.(2020). Opioids in post-stroke pain: a systematic review and meta-analysis.Front.Pharmacol.11,587050.
[5] Mohanan, A.T.,Nithya,S.,Nomier, Y., Hassan, D. A., Jali, A. M.,Qadri,M.,et al.(2023). Stroke-induced central pain: overview of the mechanisms, management,and emerging targets of central post-stroke pain.Pharmaceuticals (Basel)16:1103.
[6] Banerjee, M.,Pal, S.,Bhattacharya, B., Ghosh, B., Mondal, S., and Basu, J. (2013).A comparative study of efficacy and safety of gabapentin versus amitriptyline as coanalgesics in patients receiving opioid analgesics for neuropathic pain inmalignancy.Indian J.Pharmacol.45,334-338..
[7] Kumar,G.,and Soni,C.R. (2009). Central post-stroke pain: current evidence.J.Neurol.Sci.284,10-17.
[8] Siebner HR,Rothwell J.Transcranial magnetic stimulati on:new insights into representational cortical plasticity. Exp Brain Res 2003;148:1-16.
[9] Pascual-Leone A, Valls-Sole J, Wassermann EM, Hallett M.Responses to repetitive transcranial magnetic stimulation of the human motor cortex.Brain 1994;117:847-58.
[10] Wu T, Sommer M, Tergau F, Paulus W. Lasting influence of repetitive transcranial magnetic stimulation on intracor tical excitability in human subjects. Neurosci Lett 2000;287:37-40.
[11] Modugno N, Nakamura Y,MacKinnon CD,Filipovic SR,Best mann S,Berardelli A, et al. Motor cortex excitability followingshort trains of repetitive magnetic stimuli. Exp Brain Res 2001;140:453-9.Ri,S.(2022).The Management of Poststroke Thal amic Pain: update in clinical practice. Diagnostics (Basel)12:1439.
[12] Leung, A.,Shirvalkar,P.,Chen, R., Kuluva, J., Vaninetti, M.,Bermudes, R.,et al.(2020). Transcranial magnetic stimulationfor pain, headache, and comorbid depression: INS-NANS expert consensus panel review and recommendation. Neuromodulation 23,267-290.
[13] Leung, A., Shirvalkar, P., Chen, R., Kuluva, J., Vaninetti,M., Bermudes, R.,et al.(2020).Transcranial magnetic stimulationfor pain, headache, and comorbid depression: INS-NANS expert consensus panel review and recommendation. Neuromodulation 23,267-290.
[14] Zhao,C.G.,Sun,W.,Ju,F.,Jiang,S.,Wang,H.,Sun,X.L.,etal.(2021).Analgesic effects of navigated repetitive transcranial magnetic stimulation in patients with acute central poststr oke pain.Pain Ther.10,1085-1100.
[15] Kadono, Y., Koguchi, K., Okada, K. I., Hosomi, K., Hiraishi, M., Ueguchi, T., et al. (2021). Repetitive transcranial magnetic stimulation restores altered functional connectivity of centr al poststroke pain model monkeys.Sci.Rep.11:6126.
[16] Lefaucheur JP,André-Obadia N,Antal A,et al.:Evidence -based guidelines on the therapeutic use of repetitive tran scranial magnetic stimulation (rTMS). Clin Neurophysiol. 2014, 125:2150-2206.10.1016/j.clinph.2014.05.021.
[17] Pan, L.J.,Zhu, H.,Zhang,X.,and Wang,X.(2022).The mechani sm and effect of repetitive transcranial magnetic stimulation for post-stroke pain. Front. Mol.Neurosci.15,1091402.
[18] LeFaucheur JP: The use of repetitive transcranial magnetic stimulation(rTMS)in chronic neuropathic pain.Neuro physiol Clin.2006,36:117-24.10.1016/j.neucli.2006.08.002.
[19] Passard A, Attal N, Benadhira R, Brasseur L, Saba G, Sichere P: Effects of unilateral repetitive transcranial magnetic stimulation of the motor cortex on chronic widesp read pain in fibromyalgia. Brain.2007,130:2661-70.
[20] O'Connell NE, Wand BM, Marston L, Spencer S, DeSouza LH: Non-invasive brain stimulation techniques for chronic pain.Cochrane Database of Syst Rev.2010,CD008208.10.1002/14651858.CD008208.pub2.
[21] Borckardt JJ,Smith AR,Reeves ST.:A pilot study invest igating the effects of fast left prefrontal rTMS on chronic neuropathic pain.Pain Med.2009,10:840-849.10.1111/j.1526 -4637.2009.00657.x.
[2] Dub,é, J.A.,and Mercier,C.(2011).Effect of pain and pain expectation on primary motor cortex excitability. Clin. Neurophysiol.122,2318-2323.
[3] Kumar, B.(2009).Central poststroke pain: a review of pathophysiology and treatment.Anesth.Analg.108,1645-1657.
[4] Scuteri,D.,Mantovani,E.,Tamburin,S.,Sandrini,G.,Corasaniti, M. T.,Bagetta, G.,et al.(2020). Opioids in post-stroke pain: a systematic review and meta-analysis.Front.Pharmacol.11,587050.
[5] Mohanan, A.T.,Nithya,S.,Nomier, Y., Hassan, D. A., Jali, A. M.,Qadri,M.,et al.(2023). Stroke-induced central pain: overview of the mechanisms, management,and emerging targets of central post-stroke pain.Pharmaceuticals (Basel)16:1103.
[6] Banerjee, M.,Pal, S.,Bhattacharya, B., Ghosh, B., Mondal, S., and Basu, J. (2013).A comparative study of efficacy and safety of gabapentin versus amitriptyline as coanalgesics in patients receiving opioid analgesics for neuropathic pain inmalignancy.Indian J.Pharmacol.45,334-338..
[7] Kumar,G.,and Soni,C.R. (2009). Central post-stroke pain: current evidence.J.Neurol.Sci.284,10-17.
[8] Siebner HR,Rothwell J.Transcranial magnetic stimulati on:new insights into representational cortical plasticity. Exp Brain Res 2003;148:1-16.
[9] Pascual-Leone A, Valls-Sole J, Wassermann EM, Hallett M.Responses to repetitive transcranial magnetic stimulation of the human motor cortex.Brain 1994;117:847-58.
[10] Wu T, Sommer M, Tergau F, Paulus W. Lasting influence of repetitive transcranial magnetic stimulation on intracor tical excitability in human subjects. Neurosci Lett 2000;287:37-40.
[11] Modugno N, Nakamura Y,MacKinnon CD,Filipovic SR,Best mann S,Berardelli A, et al. Motor cortex excitability followingshort trains of repetitive magnetic stimuli. Exp Brain Res 2001;140:453-9.Ri,S.(2022).The Management of Poststroke Thal amic Pain: update in clinical practice. Diagnostics (Basel)12:1439.
[12] Leung, A.,Shirvalkar,P.,Chen, R., Kuluva, J., Vaninetti, M.,Bermudes, R.,et al.(2020). Transcranial magnetic stimulationfor pain, headache, and comorbid depression: INS-NANS expert consensus panel review and recommendation. Neuromodulation 23,267-290.
[13] Leung, A., Shirvalkar, P., Chen, R., Kuluva, J., Vaninetti,M., Bermudes, R.,et al.(2020).Transcranial magnetic stimulationfor pain, headache, and comorbid depression: INS-NANS expert consensus panel review and recommendation. Neuromodulation 23,267-290.
[14] Zhao,C.G.,Sun,W.,Ju,F.,Jiang,S.,Wang,H.,Sun,X.L.,etal.(2021).Analgesic effects of navigated repetitive transcranial magnetic stimulation in patients with acute central poststr oke pain.Pain Ther.10,1085-1100.
[15] Kadono, Y., Koguchi, K., Okada, K. I., Hosomi, K., Hiraishi, M., Ueguchi, T., et al. (2021). Repetitive transcranial magnetic stimulation restores altered functional connectivity of centr al poststroke pain model monkeys.Sci.Rep.11:6126.
[16] Lefaucheur JP,André-Obadia N,Antal A,et al.:Evidence -based guidelines on the therapeutic use of repetitive tran scranial magnetic stimulation (rTMS). Clin Neurophysiol. 2014, 125:2150-2206.10.1016/j.clinph.2014.05.021.
[17] Pan, L.J.,Zhu, H.,Zhang,X.,and Wang,X.(2022).The mechani sm and effect of repetitive transcranial magnetic stimulation for post-stroke pain. Front. Mol.Neurosci.15,1091402.
[18] LeFaucheur JP: The use of repetitive transcranial magnetic stimulation(rTMS)in chronic neuropathic pain.Neuro physiol Clin.2006,36:117-24.10.1016/j.neucli.2006.08.002.
[19] Passard A, Attal N, Benadhira R, Brasseur L, Saba G, Sichere P: Effects of unilateral repetitive transcranial magnetic stimulation of the motor cortex on chronic widesp read pain in fibromyalgia. Brain.2007,130:2661-70.
[20] O'Connell NE, Wand BM, Marston L, Spencer S, DeSouza LH: Non-invasive brain stimulation techniques for chronic pain.Cochrane Database of Syst Rev.2010,CD008208.10.1002/14651858.CD008208.pub2.
[21] Borckardt JJ,Smith AR,Reeves ST.:A pilot study invest igating the effects of fast left prefrontal rTMS on chronic neuropathic pain.Pain Med.2009,10:840-849.10.1111/j.1526 -4637.2009.00657.x.
Copyright © 2025 杨睿琰, 拜承萍
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License