Juvenile Ovarian Granulosa Cell Tumor - A Case Report

Journal: Advances in Medicine and Engineering Interdisciplinary Research DOI: 10.32629/ameir.v1i2.1216

Rubí Quero, Manuel Camacho, Yubisay Mundaraín

Institute of Oncology Dr. Luis Razetti, Venezuela


The granulosa cell tumor is an unusual ovarian tumor, even more so in pediatric age. The literature indicates that the prevalence and the incidence is more higher in patients after the fifth decade of the life with a frequency of 3.4 % of all ovarian malignancies, since most of them correspond to the benign pathologies. The tumor produces symptoms derived from the secretion of the estradiol. The granulosa cell tumor has been described as better prognosis, less aggressive than other ovarian neoplasms and the natural history was longer. Surgery is the main diagnostic, staging and therapeutic approach. The adjuvant chemotherapy is recommended only in the early stages with risk factors or in the advanced stages, as it can improve disease-free and relapse-free survival rates, such as radiation therapy. So far, the most commonly used regimens are bleomycin, etoposide, and cisplatin, with a high reaction rate. Whenever possible, surgical rescue is proposed.


cancer; cells; granulosa; tumor; pediatrics


[1] Schumer ST, Cannistra SA. Granulosa Cell Tumor of the Ovary. J Clin Oncol. 2003;6:1180-1189.
[2] Piura B, Nemet D, Yanai-Inbar I, Cohen Y, Glezerman M. Granulosa Cell Tumors of the Ovary: A Study of 18 Cases. J Surg Oncol. 1994;55:71-77.
[3] Young RH, Dickersin GR, Scully RE. Juvenile Granulosa Cell Tumors of the Ovary: A Clinic Pathologic Analysis of 125 Cases. Am J Surg Pathol. 1984;8:575-596.
[4] Cannistra SA. Cancer of the Ovary. N Engl J Med. 1993;329:1550-1559.
[5] Miller BE, Barron BA, Wan JY, Delmore JE, Silva EG, Gershenson DM. Prognostic Factors in Adult Granulosa Cell Tumors of the Ovary. Cancer. 1997;79:1951-1955.
[6] Camlibel FT, Caputo TA. Chemotherapy of Granulosa Cell Tumors. Am J Obstet Gynecol. 1983;145:763-765.
[7] Savage P, Constenla D, Fisher C, Shepherd JH, Barton DP, Blake P, et al. Granulosa Cell Tumors of the Ovary: Demographics, Survival and the Management of Advanced Disease. Clin Oncol (R Coll Radiol). 1998;10:242-245.
[8] Fujimoto T, Sakuragi N, Okuyama K, Fujino T, Yamashita K, Yamashiro S, et al. Histopathologic Prognostic Factors of Adult Granulosa Cell Tumors of the Ovary. Acta Obstet Gynecol Scand. 2001;80:1069-1074.
[9] Hildebrant RH, Rouse RV, Longacre TA. Value of Inhibin in the Identification of Granulosa Cell Tumors of the Ovary. Hum Pathol. 1997;28:1387-1395
[10] Homesley HD, Bundy BN, Hurteau JA, Roth LM. Bleomycin, Etoposide and Cisplatin Combination Therapy of Ovarian Granulosa Cell Tumors and Other Stromal Malignancies: A Gynecologic Oncology Group study. Gynecol Oncol. 1999;72:131-137.

Copyright © 2023 Rubí Quero, Manuel Camacho, Yubisay Mundaraín

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License