Journal of Clinical Medicine Research

Objective: To explore the epidemiological transmission patterns of Chikungunya Fever (CHIK) in Southeast Asia, analyze its main influencing factors, evaluate the effectiveness of existing cross-border prevention and control strategies, and provide a scientific basis for regional coordinated prevention and control. Methods: Publicly reported CHIK case data, meteorological data (temperature, precipitation), and population mobility data from the ten countries of the Association of Southeast Asian Nations (ASEAN) between 2018 and 2023 were collected. Descriptive epidemiological analysis and correlation regression analysis were conducted. Meanwhile, a systematic review and comparison were performed on the current prevention and control strategies of various countries, including border health quarantine, mosquito vector monitoring and control, and cross-border information sharing. Results: The CHIK epidemic in Southeast Asia showed obvious seasonal (high incidence in the rainy season) and regional (high incidence in urban and suburban areas) patterns. The number of cases was significantly positively correlated with average temperature (r=0.752, P<0.01) and precipitation (r=0.684, P<0.01). Cross-border human mobility was a key driving factor for the cross-regional spread of the epidemic. Regions adopting the integrated cross-border joint prevention and control model of "monitoring-early warning-joint response" showed significantly better epidemic outbreak scale and control speed than those adopting a single domestic prevention and control strategy (P<0.05). Conclusion: The transmission of CHIK in Southeast Asia is jointly influenced by natural climatic factors and human social activities. Constructing and improving regional information sharing platforms, unifying mosquito vector control standards, and strengthening comprehensive cross-border joint prevention and control strategies such as port quarantine and community mobilization are the keys to effectively curbing the cross-border spread of the epidemic.