Preparation and Characterization of a W/O Composite Camellia Microemulsion for Cosmetic Applications
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i3.4420
Abstract
Camellia seed oil (CA) is a promising cosmetic raw material with excellent antioxidant and reparative properties. In this study, a W/O composite camellia microemulsion (CCME) was prepared using a mixture of camellia seed oil and surfactants (soy lecithin and dipropylene glycol, Km=2.5:1) at a 5:5 ratio. The physicochemical properties were investigated, including average particle size, zeta potential, and storage stability. DLS results showed that the values of the average particle size and the polydispersity index (PDI) for the obtained CCME prepared under the optimized conditions were 68.96±2.91nm and 0.267±0.015. The formulation exhibited excellent centrifugal and static stability, facilitating its application in cosmetic products. Compared to pure camellia seed oil, the composite camellia microemulsion showed significantly higher DPPH radical scavenging capacity (88.25 ± 2.13%, P < 0.05). In skin-soothing efficacy tests using a 3D skin model, the composite microemulsion demonstrated superior repair effects over camellia seed oil. Further verification revealed that this enhanced reparative performance may be attributed to its upregulated expression of skin barrier structural proteins such as loricrin (LOR). In conclusion, the composite camellia microemulsion developed in this work exhibits favorable application potential and efficacy, indicating its significant benefits for cosmetic applications.
Keywords
camellia seed oil; microemulsion; W/O; skin permeation; transdermal delivery; skin barrier repair; cosmetics
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