Exploration of the Mechanism of Novel RNA m6A Methyltransferase METTL7B in Hypertension-Induced Vascular Injury
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i3.4408
Abstract
In recent years, RNA m6A methylation has emerged as an important epigenetic regulatory mechanism. The newly identified methyltransferase METTL7B plays a crucial role in this process; however, its specific mechanisms in hypertension and related vascular injury remain unclear. This review synthesizes current knowledge regarding the structure and function of METTL7B, the impact of hypertension on vascular health, and the potential role of m6A methylation in vascular injury. We explore the regulatory mechanisms by which METTL7B may influence these processes, offering new perspectives for future research.
Keywords
RNA m6A methylation; METTL7B; hypertension; vascular injury; mechanism of action
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[2] Saleem M, Masenga SK, Ishimwe JA, et al. Recent Advances in Understanding Peripheral and Gut Immune Cell-Mediated Salt-Sensitive Hypertension and Nephropathy. Hypertension. 2024;81(3):436-446. doi:10.1161/HYPERTENSIONAHA.123.22031
[3] Tomiyama H. Vascular function: a key player in hypertension. Hypertens Res. 2023;46(9):2145-2158. doi:10.1038/s41440-023-01354-3
[4] Huo KG, Richer C, Berillo O, et al. miR-431-5p Knockdown Protects Against Angiotensin II-Induced Hypertension and Vascular Injury. Hypertension.2019;73(5):1007-1017. doi:10.1161/HYPERTENSIONAHA.119.12619
[5] Liu Y, Yin HL, Li C, et al. Sinapine Thiocyanate Ameliorates Vascular Endothelial Dysfunction in Hypertension by Inhibiting Activation of the NLRP3 Inflammasome. Front Pharmacol. 11:620159. Published 2020. doi:10.3389/fphar.2020.620159
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[7] Xiong Y, Li M, Bai J, Sheng Y, Zhang Y. High Level of METTL7B Indicates Poor Prognosis of Patients and Is Related to Immunity in Glioma. Front Oncol. 11:650534. Published 2021. doi:10.3389/fonc.2021.650534
[8] Li R, Mu C, Cao Y, Fan Y. METTL7B serves as a prognostic biomarker and promotes metastasis of lung adenocarcinoma cells. Ann Transl Med. 2022;10(16):895. doi:10.21037/atm-22-3849
[9] Liu D, Li W, Zhong F, et al. METTL7B Is Required for Cancer Cell Proliferation and Tumorigenesis in Non-Small Cell Lung Cancer. Front Pharmacol. 11:178. Published 2020. doi:10.3389/fphar.2020.00178
[10] Xu L, Peng B, Wu H, Zheng Y, Yu Q, Fang S. METTL7B contributes to the malignant progression of glioblastoma by inhibiting EGR1 expression. Metab Brain Dis. 2022;37(4):1133-1143. doi:10.1007/s11011-022-00925-6
[11] Huang D, Yan H. Methyltransferase like 7B is upregulated in sepsis and modulates lipopolysaccharide-induced inflammatory response and macrophage polarization. Bioengineered. 2022;13(5):11753-11766. doi:10.1080/21655979.2022.2068892
[12] Nguyen BA, Alexander MR, Harrison DG. Immune mechanisms in the pathophysiology of hypertension. Nat Rev Nephrol. 2024;20(8):530-540. doi:10.1038/s41581-024-00838-w
[13] Yang Q, Hori M. Characterization of Contractile Machinery of Vascular Smooth Muscles in Hypertension. Life (Basel). 2021;11(7). Published 2021 Jul 16. doi:10.3390/life11070702
[14] Totoń-Żurańska J, Mikolajczyk TP, Saju B, Guzik TJ. Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation. Clin Sci (Lond). 2024;138(13):817-850. doi:10.1042/CS20220797
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[16] Koubar SH, Garcia-Rivera A, Mohamed MMB, Hall JE, Hall ME, Hassanein M. Underlying Mechanisms and Treatment of Hypertension in Glomerular Diseases. Curr Hypertens Rep. 2024;26(3):119-130. doi:10.1007/s11906-023-01287-9
[17] Santana-Garrido Á, Reyes-Goya C, Fernández-Bobadilla C, et al. NADPH oxidase-induced oxidative stress in the eyes of hypertensive rats. Mol Vis. 27:161-178. Published 2021.
[18] Chen D, Xu W, Zheng H, et al. The methyltransferase METTL3 regulates endothelial cell proliferation and inflammation via m6A RNA methylation-mediated TRAF1 expression. Biochem Biophys Res Commun. 732:150399. doi:10.1016/j.bbrc.2024.150399
[19] Xu Z, Qiu P, Jiang Y, et al. m6A Modification Mediates Endothelial Cell Responses to Oxidative Stress in Vascular Aging Induced by Low Fluid Shear Stress. Oxid Med Cell Longev. 2023:8134027. Published 2023. doi:10.1155/2023/8134027
[20] Chen LH, Zhao YY, Huang L, et al. The potential roles of RNA N6-methyladenosine in atherosclerosis. Eur Rev Med Pharmacol Sci. 2022;26(4):1075-1083. doi:10.26355/eurrev_202202_28096
[21] Zhao Y, Xia A, Li C, et al. Methyltransferase like 3-mediated N6-methylatidin methylation inhibits vascular smooth muscle cells phenotype switching via promoting phosphatidylinositol 3-kinase mRNA decay. Front Cardiovasc Med. 9:913039. Published 2022. doi:10.3389/fcvm.2022.913039
[22] Zhang BF, Wu ZH, Deng J, et al. M6A methylation-mediated elevation of SM22α inhibits the proliferation and migration of vascular smooth muscle cells and ameliorates intimal hyperplasia in type 2 diabetes mellitus. Biol Chem. 2022;403(3):317-329. Published 2022 Feb 23. doi:10.1515/hsz-2021-0296
[23] Zhou Q, Tian M, Cao Y, et al. YTHDC1 aggravates high glucose-induced retinal vascular endothelial cell injury via m6A modification of CDK6. Biol Direct. 2024;19(1):54. Published 2024 Jul 8. doi:10.1186/s13062-024-00498-7
[24] Lü X, Fan Y, Kang S, Xiao B, Zhang M. RNA methylation and neurovascular unit remodeling. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021;46(5):536-544. doi:10.11817/j.issn.1672-7347.2021.200246
[25] Lin Y, Luo G, Liu Q, Yang R, Sol Reinach P, Yan D. METTL3-Mediated RNA m6A Modification Regulates the Angiogenic Behaviors of Retinal Endothelial Cells by Methylating MMP2 and TIE2. Invest Ophthalmol Vis Sci. 2023;64(13):18. doi:10.1167/iovs.64.13.18
[26] Gu N, Shen Y, He Y, et al. Loss of m6A demethylase ALKBH5 alleviates hypoxia-induced pulmonary arterial hypertension via inhibiting Cyp1a1 mRNA decay. J Mol Cell Cardiol. 194:16-31. doi:10.1016/j.yjmcc.2024.05.013
[27] Li S, Hu W, Gong S, et al. The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice. Adv Sci (Weinh). 2023;10(25):e2300892. doi:10.1002/advs.202300892
[28] Hu L, Wang J, Huang H, et al. YTHDF1 Regulates Pulmonary Hypertension through Translational Control of MAGED1. Am J Respir Crit Care Med. 2021;203(9):1158-1172. doi:10.1164/rccm.202009-3419OC
[29] Fu R, Luo X, Ding Y, Guo S. Prognostic Potential of METTL7B in Glioma. Neuroimmunomodulation. 2022;29(3):186-201. doi:10.1159/000519778
[30] Zheng D, Jiang J, Shen A, Zhong Y, Zhang Y, Xiu J. Maternal Hypertension Aggravates Vascular Dysfunction After Injury in Male Adult Offspring Through Transgenerational Transmission of N6-Methyladenosine. Hypertension. . Published online Dec 17,2024. doi:10.1161/HYPERTENSIONAHA.124.23373
[31] Ali J, Liu W, Duan W, et al. METTL7B (methyltransferase-like 7B) identification as a novel biomarker for lung adenocarcinoma. Ann Transl Med. 2020;8(18):1130. doi:10.21037/atm-20-4574
[32] Zhang R, Qu Y, Ji Z, et al. METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner. Cell Mol Biol Lett. 2022;27(1):55. Published 2022 Jul 14. doi:10.1186/s11658-022-00349-1
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