Correlation Study of Cognitive Function and Brain Spectral Metabolism,White Matter Hyperintensity in Patients with OSAHS
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i2.3896
Abstract
Sleep is an essential physiological process in human life. When people sleep, numerous cellular reactions occur, develop, and interact. These reactions facilitate bodily repair and regeneration,providing better mental and physical support for the following day. Despite its importance, sleep problems are widespread throughout the population. According to the International Classification of Sleep Disorders, 3rd Edition (ICSD-3), released in 2014, sleep disorders are categorized into several types. These include Sleep-related breathing disorders, Central disorders of hypersomnolence, Circadian rhythm sleep-wake disorders, Insomnia, Parasomnias and Sleep-related movement disorders.
Keywords
obstructive sleep apnea hypopnea syndrome; cognitive function; hydrogen proton magnetic resonance spectroscopy; white matter high signa
Full Text
PDF - Viewed/Downloaded: 3 TimesReferences
[1]Young T, Peppard P E, Gottlieb D J. Epidemiology of obstructive sleep apnea: a population health perspective[J]. American journal of respiratory and critical care medicine, 2002, 165(9): 1217-1239.
[2]Krakow B, Melendrez D, Ferreira E, et al. Prevalence of insomnia symptoms in patients with sleep disordered breathing[J]. Chest 2001;120:1923-9.
[3]Kuvat N, Tanriverdi H, Armutcu F. The relationship between obstructive sleep apnea syndrome and obesity: A new perspective on the pathogenesis in terms of organ crosstalk[J]. The Clinical Respiratory Journal,2020,14.
[4]Stradling JR, Davies RJ. Sleep. 1: Obstructive sleep apnoea/hypopnoea syndrome: definitions, epidemiology, and natural history[J]. Thorax. 2004;59(1):73-78.
[5]Libby P, Ridker P M, Maseri A. Inflammation and atherosclerosis[J]. Circulation, 2002, 105(9): 1135-1143.
[6]Lavie L. Oxidative stress in obstructive sleep apnea and intermittent hypoxia--revisited--the bad ugly and good: implications to the heart and brain[J]. Sleep Med Rev. 2015;20:27-45.
[7]Savarimuthu A, Ponniah RJ. Cognition and Cognitive Reserve[J]. Integr Psychol Behav Sci. 2024;58(2):483-501.
[8]Nurliyana, A. R., Shariff, M., Mohd Taib, Z., et al. Early growth and home environment are associated with cognitive development in the first year of life of Malaysian infants[J].Early Human Development. 2019.104890.
[9]Posner MI, Sheese BE, Odludaş Y,et al. Analyzing and shaping human attentional networks[J]. Neural Networks, 2006,19(9):1422-1429.
[10]Fan J, McCandliss BD, Fossella J,et al: The activation of attentional networks[J]. Neuroimage, 2005; 26(2): 471-79.
[11]Rinne P, Hassan M, Goniotakis D,et al. Triple dissociation of attention networks in stroke according to lesion location[J]. Neurology, 2013; 81(9): 812-20.
[12]Karakaş S. Bilnot battery handbook: research and development studies of neuropsychological tests[J]. Ankara: Eryılmaz Offset Matbaacılık Gazetecilik; 2006.
[13]Beebe DW, Gozal D. Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioural deficits[J]. Sleep Res 2002; 11: 1-16.
[14]Mazza S, Pépin JL, Naëgelé B, etc. Most Obstructive Sleep Apnoea Patients Exhibit Vigilance and Attention Deficits on an Extended Battery of Tests[J]. European Respiratory Journal, 2005, 25(1): 75-80.
[15]Seda G, Han TS. Effect of Obstructive Sleep Apnea on Neurocognitive Performance[J]. Sleep Med Clin. 2020;15(1):77-85.
[16]Martin SE, Brander PE, Deary IJ, et al. The effect of clustered versus regular sleep fragmentation on daytime function[J].Sleep Res. 1999;8:305-311.
[17]Zhang, X., Ma, L., Li, S.,et al. A functional MRI evaluation of frontal dysfunction in patients with severe obstructive sleep apnea[J]. Sleep medicine 12, 335-340.
[18]Tulek B, Atalay NB, Kanat F. Attentional control is partially impaired in obstructive sleep apnea syndrome[J]. Sleep Res. 2013;22(4):422-429.
[19]Zhu Y, Fenik P, Zhan G, et al. Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model[J].Neurosci. 2007;27:10060-10071.
[20]2001-2011: a decade of the LADIS (Leukoaraiosis And DISability) Study: what have we learned about white matter changes and small-vessel disease[J]?Cerebrovascular diseases (Basel, Switzerland),2011,32(6):577-588.
[21]Wardlaw JM, Valdés Hernández MC,Muñoz-Maniega S.What are white matter hyperintensities made of? Relevance to vascular cognitive impairment[J].Journal of the American Heart Association,2015,4(6):001140.
[22]Wen W, Sachdev PS, Li JJ, et al.White matter hyperintensities in the forties: their prevalence and topography in an epidemiological sample aged 44-48[J].Human brain mapping,2009,30(4):1155-1167.
[23]Hajjar I, Quach L, Yang F, et al.Hypertension, white matter hyperintensities, and concurrent impairments in mobility, cognition, and mood: the Cardiovascular Health Study[J].Circulation,2011,123(8):858-865.
[24]Karcher HS, Holzwarth R, Mueller HP, et al.Body fat distribution as a risk factor for cerebrovascular disease: an MRI-based body fat quantification study[J].Cerebrovascular diseases (Basel, Switzerland),2013,35(4):341-348.
[25]Griffanti L, Jenkinson M, Suri S, et al.Classification and characterization of periventricular and deep white matter hyperintensities on MRI: A study in older adults[J].NeuroImage,2018,170(1):174-181.
[26]Rowbotham GF and Little E.A NEW CONCEPT OF THE CIRCULATION AND THE CIRCULATIONS OF THE BRAIN. THE DISCOVERY OF SURFACE ARTE RIOVENOUS SHUNTS[J].The British journal of surgery,1965,52(2):539-542.
[27]Kim KW, MacFall JR,Payne ME.Classification of white matter lesions on ma gnetic resonance imaging in elderly persons[J].Biological psychiatry,2008,64(4):273-280.
[28]Choi K M, Thomas R J, Yoon D W, et al. Interaction between Obstructive Sleep Apnea and Shortened Telomere Length on Brain White Matter Abnormality[J]. Sleep, 2016, 39(9): 1639-45.
[29]Taylor KS, Millar PJ, Murai H, et al. Cortical autonomic network gray matter and sympathetic nerve activity in obstructive sleep apnea[J]. Sleep. 2018;41(2):zsx208.
[30]Soares D P, Law M. Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications[J]. Clinical radiology, 2009, 64(1): 12-21.
[31]Urenjak J, Williams S R, Gadian D G, et al. Specific expression of N‐acetylaspartate in neurons, oligodendrocyte‐type‐2 astrocyte progenitors, and immature oligodendrocytes in vitro[J]. Journal of neurochemistry, 1992, 59(1): 55-61.
[32]O'Donoghue F J, Wellard R M, Rochford P D, et al. Magnetic resonance spectroscopy and neurocognitive dysfunction in obstructive sleep apnea before and after CPAP treatment[J]. Sleep, 2012, 35(1): 41-48.
[33]Soares D P, Law M. Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications[J]. Clinical radiology, 2009, 64(1): 12-21.
[34]Urenjak J, Williams S R, Gadian D G, et al. Specific expression of N‐acetylaspartate in neurons, oligodendrocyte‐type‐2 astrocyte progenitors, and immature oligodendrocytes in vitro[J]. Journal of neurochemistry, 1992, 59(1): 55-61.
[35]O'Donoghue F J, Wellard R M, Rochford P D, et al. Magnetic resonance spectroscopy and neurocognitive dysfunction in obstructive sleep apnea before and after CPAP treatment[J]. Sleep, 2012, 35(1): 41-48.
[36]Togeiro S. M., Carneiro G., Ribeiro Filho F. F., et al.Consequences of Obstructive Sleep Apnea on Metabolic Profile: a Population-Based Survey[J]. Obes. (Silver Spring) 21 (4), 847-851.
[37]Wu ZH, Yang XP, Niu X, et al. The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease：a meta-analysis[J]. Sleep Breath, 2019, 23（2）：389-397.
[38]Algin O, Gokalp G, Ocakoglu G, et al. Neurochemical-structural changes evaluation of brain in patients with obstructive sleep apnea syndrome[J]. European journal of radiology, 2012, 81(3): 491-495.
[39]Karcher HS, Holzwarth R, Mueller HP, et al.Body fat distribution as a risk factor for cerebrovascular disease: an MRI-based body fat quantification study[J].Cerebrovascular diseases (Basel, Switzerland),2013,35(4):341-348.
[2]Krakow B, Melendrez D, Ferreira E, et al. Prevalence of insomnia symptoms in patients with sleep disordered breathing[J]. Chest 2001;120:1923-9.
[3]Kuvat N, Tanriverdi H, Armutcu F. The relationship between obstructive sleep apnea syndrome and obesity: A new perspective on the pathogenesis in terms of organ crosstalk[J]. The Clinical Respiratory Journal,2020,14.
[4]Stradling JR, Davies RJ. Sleep. 1: Obstructive sleep apnoea/hypopnoea syndrome: definitions, epidemiology, and natural history[J]. Thorax. 2004;59(1):73-78.
[5]Libby P, Ridker P M, Maseri A. Inflammation and atherosclerosis[J]. Circulation, 2002, 105(9): 1135-1143.
[6]Lavie L. Oxidative stress in obstructive sleep apnea and intermittent hypoxia--revisited--the bad ugly and good: implications to the heart and brain[J]. Sleep Med Rev. 2015;20:27-45.
[7]Savarimuthu A, Ponniah RJ. Cognition and Cognitive Reserve[J]. Integr Psychol Behav Sci. 2024;58(2):483-501.
[8]Nurliyana, A. R., Shariff, M., Mohd Taib, Z., et al. Early growth and home environment are associated with cognitive development in the first year of life of Malaysian infants[J].Early Human Development. 2019.104890.
[9]Posner MI, Sheese BE, Odludaş Y,et al. Analyzing and shaping human attentional networks[J]. Neural Networks, 2006,19(9):1422-1429.
[10]Fan J, McCandliss BD, Fossella J,et al: The activation of attentional networks[J]. Neuroimage, 2005; 26(2): 471-79.
[11]Rinne P, Hassan M, Goniotakis D,et al. Triple dissociation of attention networks in stroke according to lesion location[J]. Neurology, 2013; 81(9): 812-20.
[12]Karakaş S. Bilnot battery handbook: research and development studies of neuropsychological tests[J]. Ankara: Eryılmaz Offset Matbaacılık Gazetecilik; 2006.
[13]Beebe DW, Gozal D. Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioural deficits[J]. Sleep Res 2002; 11: 1-16.
[14]Mazza S, Pépin JL, Naëgelé B, etc. Most Obstructive Sleep Apnoea Patients Exhibit Vigilance and Attention Deficits on an Extended Battery of Tests[J]. European Respiratory Journal, 2005, 25(1): 75-80.
[15]Seda G, Han TS. Effect of Obstructive Sleep Apnea on Neurocognitive Performance[J]. Sleep Med Clin. 2020;15(1):77-85.
[16]Martin SE, Brander PE, Deary IJ, et al. The effect of clustered versus regular sleep fragmentation on daytime function[J].Sleep Res. 1999;8:305-311.
[17]Zhang, X., Ma, L., Li, S.,et al. A functional MRI evaluation of frontal dysfunction in patients with severe obstructive sleep apnea[J]. Sleep medicine 12, 335-340.
[18]Tulek B, Atalay NB, Kanat F. Attentional control is partially impaired in obstructive sleep apnea syndrome[J]. Sleep Res. 2013;22(4):422-429.
[19]Zhu Y, Fenik P, Zhan G, et al. Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model[J].Neurosci. 2007;27:10060-10071.
[20]2001-2011: a decade of the LADIS (Leukoaraiosis And DISability) Study: what have we learned about white matter changes and small-vessel disease[J]?Cerebrovascular diseases (Basel, Switzerland),2011,32(6):577-588.
[21]Wardlaw JM, Valdés Hernández MC,Muñoz-Maniega S.What are white matter hyperintensities made of? Relevance to vascular cognitive impairment[J].Journal of the American Heart Association,2015,4(6):001140.
[22]Wen W, Sachdev PS, Li JJ, et al.White matter hyperintensities in the forties: their prevalence and topography in an epidemiological sample aged 44-48[J].Human brain mapping,2009,30(4):1155-1167.
[23]Hajjar I, Quach L, Yang F, et al.Hypertension, white matter hyperintensities, and concurrent impairments in mobility, cognition, and mood: the Cardiovascular Health Study[J].Circulation,2011,123(8):858-865.
[24]Karcher HS, Holzwarth R, Mueller HP, et al.Body fat distribution as a risk factor for cerebrovascular disease: an MRI-based body fat quantification study[J].Cerebrovascular diseases (Basel, Switzerland),2013,35(4):341-348.
[25]Griffanti L, Jenkinson M, Suri S, et al.Classification and characterization of periventricular and deep white matter hyperintensities on MRI: A study in older adults[J].NeuroImage,2018,170(1):174-181.
[26]Rowbotham GF and Little E.A NEW CONCEPT OF THE CIRCULATION AND THE CIRCULATIONS OF THE BRAIN. THE DISCOVERY OF SURFACE ARTE RIOVENOUS SHUNTS[J].The British journal of surgery,1965,52(2):539-542.
[27]Kim KW, MacFall JR,Payne ME.Classification of white matter lesions on ma gnetic resonance imaging in elderly persons[J].Biological psychiatry,2008,64(4):273-280.
[28]Choi K M, Thomas R J, Yoon D W, et al. Interaction between Obstructive Sleep Apnea and Shortened Telomere Length on Brain White Matter Abnormality[J]. Sleep, 2016, 39(9): 1639-45.
[29]Taylor KS, Millar PJ, Murai H, et al. Cortical autonomic network gray matter and sympathetic nerve activity in obstructive sleep apnea[J]. Sleep. 2018;41(2):zsx208.
[30]Soares D P, Law M. Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications[J]. Clinical radiology, 2009, 64(1): 12-21.
[31]Urenjak J, Williams S R, Gadian D G, et al. Specific expression of N‐acetylaspartate in neurons, oligodendrocyte‐type‐2 astrocyte progenitors, and immature oligodendrocytes in vitro[J]. Journal of neurochemistry, 1992, 59(1): 55-61.
[32]O'Donoghue F J, Wellard R M, Rochford P D, et al. Magnetic resonance spectroscopy and neurocognitive dysfunction in obstructive sleep apnea before and after CPAP treatment[J]. Sleep, 2012, 35(1): 41-48.
[33]Soares D P, Law M. Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications[J]. Clinical radiology, 2009, 64(1): 12-21.
[34]Urenjak J, Williams S R, Gadian D G, et al. Specific expression of N‐acetylaspartate in neurons, oligodendrocyte‐type‐2 astrocyte progenitors, and immature oligodendrocytes in vitro[J]. Journal of neurochemistry, 1992, 59(1): 55-61.
[35]O'Donoghue F J, Wellard R M, Rochford P D, et al. Magnetic resonance spectroscopy and neurocognitive dysfunction in obstructive sleep apnea before and after CPAP treatment[J]. Sleep, 2012, 35(1): 41-48.
[36]Togeiro S. M., Carneiro G., Ribeiro Filho F. F., et al.Consequences of Obstructive Sleep Apnea on Metabolic Profile: a Population-Based Survey[J]. Obes. (Silver Spring) 21 (4), 847-851.
[37]Wu ZH, Yang XP, Niu X, et al. The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease：a meta-analysis[J]. Sleep Breath, 2019, 23（2）：389-397.
[38]Algin O, Gokalp G, Ocakoglu G, et al. Neurochemical-structural changes evaluation of brain in patients with obstructive sleep apnea syndrome[J]. European journal of radiology, 2012, 81(3): 491-495.
[39]Karcher HS, Holzwarth R, Mueller HP, et al.Body fat distribution as a risk factor for cerebrovascular disease: an MRI-based body fat quantification study[J].Cerebrovascular diseases (Basel, Switzerland),2013,35(4):341-348.
Copyright © 2025 Chaoying Hu, Chengping Bai
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
