Reprogramming Mechanisms and Application Prospects of Induced Pluripotent Stem Cells
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v6i1.3709
Abstract
The technology of induced pluripotent stem cells (iPSCs) is of great significance.The reprogramming mechanism is to transform somatic cells from epigenetic modification to pluripotent state through transcription factors (such as OKSM), which involves a complex process such as chromatin remodeling, and the methods include transcription factor induction, vector introduction and small molecule compound assistance. However, this technology faces challenges such as low reprogramming efficiency, high safety risks and ethical controversies.In terms of applications, iPSCs can be used to construct disease models and drug screening , helping regenerative medicine, tissue engineering and personalized treatment. However, there are problems such as cellular heterogeneity and immunogenicity. In the future, it is necessary to optimize the reprogramming efficiency and stability, reduce the risk of carcinogenesis, unify the quality control standards, strengthen the ethical regulations, so as to promote the in-depth application of iPSCs technology in various fields and safeguard the health and well-being of human beings.
Keywords
induced pluripotent stem cells, cell reprogramming, regenerative medicine, transcription factors, disease modeling
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