Journal of Clinical Medicine Research

Aims: To investigate the clinical effect of promoting growth patch combined with breeding and strengthening spleen ointment on children with Idiopathic Short Stature (ISS)along with syndrome of spleen and kidney deficiency. Method: A total of 80 ISS children from the Department of Child Health of Shandong Provincial Maternal and Child Health Hospital and the Department of Pediatrics of Yantai Hospital of Traditional Chinese Medicine were selected and divided into two groups by simple randomization method. The observation group was treated with the combination of growth promotion patch and breeding and strengthening spleen ointment, while the control group was handled with routine treatment. After 6 months of treatment, the growth status (height, height growth rate (GV), bone age, etc.), and traditional Chinese medicine (TCM) syndrome score were compared between the two groups of children before and after medication. Meanwhile, the expression levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), and 25 hydroxyvitamin D [25-(OH) D] were detected, and the children's sleep questionnaire (PSQ) scores and incidence of adverse reactions were compared. Results: After treatment, the height, weight, bone age and GV of the two groups were significantly increased compared with that before treatment, and the growth rate of the observation group was higher than that of the control group (P<0.05). The clinical effective rate of the observation group was 97.5%, which was higher than that of the control group (65%). In addition, the TCM symptom score of the observation group after treatment was significantly lower than that of the control group (P<0.05). The levels of IGF-1, IGFBP-3, and 25 (OH) D in the observation group were higher than those in the control group (P<0.05). Meanwhile, after treatment, the PSQ scores of the observation group were significantly lower than those of the control group (P<0.05), and there was no significant difference in adverse reactions between the two groups of children during treatment (P>0.05). Conclusion: The combined application of growth-promoting patch and breeding and strengthening spleen ointment could significantly improve the clinical symptoms of children with ISS, effectively promoted the growth and development of children with ISS, regulated the levels of IGF-1, IGFBP-3 and 25(OH)D, and significantly improved the sleep of children with a low incidence of adverse reactions.