Network Pharmacology-based Mechanistic Study on Prunellae Spica for the Treatment of Endometrial Cancer
Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v5i4.3303
Abstract
Objective: To explore the potential mechanism of action of Prunellae Spica on endometrial cancer (EC) by network pharmacology and molecular docking. Method: TCSMP database was used to screen the Prunellae Spica ingredients and corresponding targets.Screen target genes for endometrial cancer from GeneCards, OMIM, and TTD databases,and the intersection targets were analyzed for functional enrichment and biological pathways. Perform molecular docking between the top 5 core targets and the active ingredients of Prunellae Spica. Results: Network pharmacological analysis showed that there were 83 key targets of Prunellae Spica in the treatment of EC.The results of the GO analysis showed that 544 biological processes (BP), 52 cell components (CC) and 104 molecular functions (MF) were included. Molecular docking was performed between the top 5 core targets and the active ingredients of Prunellae Spica, and the results showed that the active ingredients of Prunella vulgaris have good binding ability to the key targets. Conclusion: In summary, the mechanism of action of Prunellae Spica in the treatment of EC involves multiple targets and signaling pathways. It is speculated that TP53, AKT1, JUN, BCL2, MYC, TNF, and CASP3 are key targets of Prunellae Spica in the treatment of EC, but further experimental verification is still needed.
Keywords
Prunellae Spica, endometrial cancer, network pharmacology, mechanism
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