口腔病原菌与全身性疾病关联情况的研究进展
Journal: Interdisciplinary Research on Medicine and Engineering Technology DOI: 10.12238/irmet.v3i1.16759
Abstract
口腔健康是人类健康的一个重要组成部分,人类口腔中定植着人体第二大的微生物群：口腔微生物组。在健康状态下,口腔微生物群呈动态平衡,当这个平衡被打破时不仅引起口腔疾病,还可影响全身各系统引起不同疾病。探讨口腔病原菌感染与全身疾病联系,有助于详细了解患者的病史和健康状况,为临床医生提供更全面的视角,提高治疗效果和诊断准确性,推进口腔微生物影响口腔乃至全身疾病的研究进展。本文对口腔病原菌感染及与全身各系统主要疾病的相关性进行综述。
Keywords
牙科；口腔病原菌；口腔微生物组；全身疾病
Funding
(1)浙江省教育厅一般科研项目(专业学位研究生培养模式改革专项)浙江大学科研项目资助(XY2022050)A Project Supported by Scientific Research Fund of Zhejiang University.(2)院内探索课题《DNA倍体联合涎液相关miRNA对OSCC早期指征的意义》(5022270)。(3)浙江省科技厅分析测试公益性项目《DNA倍体分析联合涎液相关miRNA检测提高口腔鳞癌早期诊断率的临床转化研究》(LGC22H140001)。(4)浙江大学双一流《新时代思想政治教育创新计划》2021年本科生(2-2050205-21-005)。(5)浙江大学医学院教育改革课题《PowerPoint-Karaoke串讲型团体教学模式在口腔黏膜病学课程教学中的应用》(yxyb20172030)。
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[34] POOLE S, SINGHRAO S K,CHUKKAPALLI S,et al.Active Invasion of Porphyromonas gingivalis and Infection-Induced Comp lement Activation in ApoE-/- Mice Brains[J].Journal of Alzhe imer's Disease,2014,43(1):67-80.
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[39] TRAN V T A,KANG Y J,KIM H K,et al.Oral Pathogenic Bacte ria-Inducing Neurodegenerative Microgliosis in Human Neural Cell Platform[J].Int J Mol Sci, 2021,22(13).
[40] ZHANG F,ZHANG W.Research progress in Alzheimer's dise ase and bone-brain axis[J].Ageing Res Rev,2024,98:102341.
[41] SCHELTENS P,DE STROOPER B,KIVIPELTO M,et al.Alzheim er's disease[J].Lancet,2021,397(10284):1577-90.
[42] MATUSZYK M M,GARWOOD C J,FERRAIUOLO L,et al.Biologic al and methodological complexities of beta-amyloid peptide:Implications for Alzheimer's disease research [J].J Neurochem, 2022,160(4):434-53.
[43] KUMAR P S.From focal sepsis to periodontal medicine: a century of exploring the role of the oral microbiome in syst emic disease[J].Journal of Physiology,2017,595(2):465-76.
[44] ROTTER V,NAGAEV I,SMITH U.Interleukin-6(IL-6)induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects[J].J Biol Chem,2003,278(46):45777-84.
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