隐丹参酮通过抑制炎症改善糖尿病心肌病小鼠的心功能
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v8i2.18923
Abstract
目的：探究隐丹参酮（cryptotanshinone，CTS）对糖尿病心肌病（Diabetic Cardiomyopathy，DCM）小鼠的保护作用。方法：将C57BL/6小鼠分为对照组、模型组、低剂量CTS组（15 mg/kg）和高剂量CTS组（30 mg/kg），通过链脲佐菌素联合高脂饮食构建DCM小鼠模型，予腹腔注射CTS治疗14天。采用心脏超声评估心功能，ELISA检测血清炎症因子水平，Western blot检测心肌组织中炎症因子蛋白表达。结果：与模型组相比，CTS治疗剂量依赖性地改善DCM小鼠左室射血分数和短轴缩短率（P<0.05），降低血清及心肌组织中IL-1β、IL-6、TNF-α表达水平（P<0.05）。结论：CTS通过抑制炎症反应改善DCM小鼠的心脏功能。
Keywords
隐丹参酮；糖尿病心肌病；心脏功能；炎症反应
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