一例持续抗凝下反复发作的特鲁索综合征及文献复习

Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v8i2.18890

范少华

北京中医药大学东直门医院洛阳医院

Abstract

特鲁索综合征以头部多个动脉供血区的多个小梗死灶,及D-二聚体显著升高为典型特征。目前西医首选低分子肝素抗凝治疗,而中医通过辨证论治,中药组方治疗,可显著促进肢体偏瘫康复,有效预防中风再发生。现报道中西医结合治疗以急性脑梗死为首发表现的特鲁索综合征1例,分享其一波三折的诊疗过程,为诊治该病提供更多的临床经验,同时提高临床医生对癌症相关血栓形成的重视,并探索抗凝治疗策略。

Keywords

特鲁索综合征;急性脑梗死;肺恶性肿瘤;依诺肝素钠注射液

References

[1] Ikushima S, Ono R, Fukuda K, et al.Trousseau’s syndrome: cancer-associated thrombosis[J].Japanese Journal of Clinical Oncology,2016,46(3):204-208.
[2] 张艳召,汪凯,张辉,等.以急性脑梗死为首发表现的隐匿性恶性肿瘤患者13例临床特点总结[J].国际神经病学神经外科学杂志,2017,44(1):58-62.
[3] Uchiyama S, Shimizu Y.Brain infarction seen in patients with malignant tumors ( Trousseau’s syndrome) [J].Neuro Med,2003,58: 463-467.
[4] 孙辉,叶静静,钱伟东,等.以脑梗死为主要表现的Trousseau综合征临床分析[J].淮海医药,2022,40(2):158-161.
[5] Matsumoto N, Fukuda H, Handa A, et al.Histological examination of Trousseau syndrome - related Thrombus retrieved through acute endo - vascular thrombectomy: report of 2 cases[J ]. Stroke Cerebrovasc Dis,2016,25(12):e227-230.
[6] NAKAO S, MASUDA T, SAKAMOTO S, et al.Cerebral embolism during edoxaban administration for venous thromboembolism in a patient with lung adenocarcinoma:a case report[J]. Medicine,2019,98(12):e14821 .
[7] NAM K W, KIM C K, KIM T J, et al.Treatment of cryptogenic stroke with active cancer with a new oral anticoagulant[J].J Stroke Cerebrovasc Dis,2017,26(12):2976-2980.
[8] SEOK J M, KIM S G, KIM J W, et al. Coagulopathy and embolic signal in cancer patients with ischemic stroke[J].Ann Neurol,2010,68(2):213-219.
[9] NAITO H, NEZU T, HOSOMI N, et al.Antithrombotic therapy strategy for cancer-associated ischemic stroke:a case series of 26 patients[J].J Stroke Cerebrovasc Dis,2018,27(9):e206- 211.

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