血清miR-501-3p对肺磨玻璃结节良恶性鉴别诊断的预测价值
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v8i2.18889
Abstract
目的：探讨血清miR-501-3p在肺磨玻璃结节（GGN）良恶性鉴别中的诊断价值。方法：收集2022.10-2024.09在成都市双流区第一人民医院确诊的GGN患者160例，分为良性组（GGN-BN）和恶性组（GGN-LUAD）各80例；另取健康对照（Normal）80例。qRT-PCR检测血清miR-501-3p水平，并结合TCGA数据库及自建组织样本验证其表达差异。ROC曲线分析miR-501-3p区分GGN良恶性的诊断效能，生存分析评估预后价值。多因素Logistic回归分析miR-501-3p鉴别诊断 GGN 良恶性的影响因素。结果：miR-501-3p在GGN-LUAD血清和组织中显著低于GGN-BN组（P < 0.01），Normal组与GGN-BN组间无显著差异。miR-501-3p区分GGN-LUAD与GGN-BN的曲线下面积（AUC）为0.771（95%CI：0.700–0.843）。miR-501-3p低表达患者总生存期较短（P = 0.332）。在控制年龄、性别、结节位置等影响因素后，miR-501-3p表达水平升高是GGN恶性风险的保护因素（OR = 0.46, P = 0.001）。结论：miR-501-3p低表达与GGN恶性风险升高及不良预后相关，血清miR-501-3p对 GGN良恶性鉴别具有一定的临床预测价值。
Keywords
肺磨玻璃结节；良恶性；miR-501-3p；鉴别诊断
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