卵巢子宫内膜异位囊肿术后药物治疗进展：GnRH-a、地诺孕素及LNG-IUS的应用
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v8i1.18542
Abstract
卵巢子宫内膜异位囊肿(OE)术后高复发率是临床关键挑战,术后药物辅助治疗以抑制残留病灶、缓解疼痛、降低复发为核心目标。本文系统综述 GnRH-a(如亮丙瑞林)、地诺孕素(DNG)、LNG-IUS 的单药疗效、安全性、疗程争议及联合策略。研究显示,GnRH-a 短期治疗(3～6个月)快速抑灶但需警惕骨丢失；DNG长期治疗(≥12个月)疗效与骨密度安全性均衡；LNG-IUS局部释药降复发,适用于无生育需求者。联合方案(如GnRH-a序贯DNG或LNG-IUS)在提升妊娠率、延缓复发上具协同效应,最佳疗程及安全性仍需大样本研究验证,本综述为临床个体化治疗提供循证依据。
Keywords
卵巢子宫内膜异位囊肿；术后治疗；促性腺激素释放激素激动剂；地诺孕素；左炔诺孕酮宫内缓释系统
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