肺栓塞预后的危险因素临床研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v7i3.14432
Abstract
在当前医疗健康领域,肺栓塞已经成为重要的医疗健康问题。而且近年来肺栓塞发病率明显升高,虽然随着医疗技术的不断进步,肺栓塞的诊疗手段有了显著提升,但是肺栓塞患者的临床表现并不典型,导致该病入院的高危患者比例明显增多,预后较差。因此,由于肺栓塞的复杂性和多变性,准确识别并评估其预后的危险因素一直是临床实践中的一大挑战。然而,肺栓塞预后的不确定性仍然给患者管理和临床决策带来了挑战。本研究通过系统性综述的方法,对国内外关于肺栓塞预后的危险因素的相关文献进行全面梳理和筛选。以揭示不同危险因素对肺栓塞预后的影响程度及其相互作用关系。以及探讨这些危险因素导致肺栓塞预后不良的作用机制,为进一步的研究及其治疗提供了新的思路和方向。
Keywords
肺栓塞；预后；危险因素；研究进展
Funding
青海省“昆仑英才–高端创新创业人才”项目。
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[1] 龙文,王玉梅.发生急性肺栓塞的临床表现及危险因素[J].齐齐哈尔医学院学报,2019,40(11):1363-1365.
[2] 孙晓莉,樊兵权,杨芸.不同部位下肢深静脉血栓形成与急性肺栓塞后肺动脉高压病情的关系及对预后的影响[J].医学理论与实践,2024,37(06):945-947.
[3] KELLER K,HOBOHM L,EBNER M,等.Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany[J/OL].European Heart Journal,2020,41(4):522-529.
[4] Freund Y,Cohen-Aubart F, Bloom B.Acute Pulmonary Embolism:A Review. JAMA.2022;328(13):1336-1345.
[5] BUMROONGKIT C, DEESOMCHOK A,LIWSRISAKUN C等.Clinical Characteristics,Risk Factors, and Outcomes of Acute Pulmonary Embolism in Asian Population[J/OL].Journal of Clinical Medic ine,2022,11(23):6954.
[6] WENGER N, SEBASTIAN T,ENGELBERGER R P,等.Pulmonary embolism and deep vein thrombosis:Similar but different[J/OL]. Thrombosis Research,2021,206:88-98.
[7] Tian H, Zhang Y, Liu J, et al. Sex disparities of clinical manifestations in acute pulmonary embolism and predictive value for in-hospital mortality: Insights from CURES.Thromb Res.2024;243:109146.doi:10.1016/j.thromres.2024.109146.
[8] ZUIN M, RIGATELLI G, ZULIANI G,等.Seizures as the first clinical manifestation of acute pulmonary embolism: an under estimate issue in neurocritical care[J/OL].NeurologicalScien ces,2020,41(6):1427-1436.
[9] KHANDAIT H,HARKUT P,KHANDAIT V,等.Acute pulmonary em bolism: Diagnosis and management[J/OL]. Indian Heart Journal, 2023,75(5):335-342.DOI:10.1016/j.ihj.2023.05.007.
[10] 李博.急性肺血栓栓塞症的临床特征、预后评估和介入诊疗研究[D].吉林大学,2024.
[11] Escolar G,Díaz-Ricart M,Arellano-Rodrigo E. Betrixa ban: a direct oral inhibitor of activated factor X for the prophylaxis of venous thromboembolism in patients hospitalized for acute medical illness.Drugs Today(Barc).2017;53(8):423-434.
[12] 李建东,郭山峰,周涛,等.肺血栓栓塞症诊疗进展[J].中国临床研究,2025,38(02):169-172+185.
[13] Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the Euro pean Respiratory Society(ERS).Eur Heart J.2020;41(4):543-603.
[14] BioMed Research International. Retracted: Treatme nt of Acute Pulmonary Embolism: Update on Newer Pharmacolo gic and Interventional Strategies [retraction of: Biomed Res Int. 2014;2014:410341. doi: 10.1155/2014/410341.].Biomed Res Int.2019;2019:4217864.Published2019Aug22.
[15] Pruszczyk P,Klok FA,Kucher N,et al.Percutaneous treat ment options for acute pulmonary embolism: a clinical consen sus statement by the ESC Working Group on Pulmonary Circulat ion and Right Ventricular Function and the European Association of Percutaneous Cardiovascular Interventions.EuroInterventi on.2022;18(8):e623-e638.Published 2022 Oct7.
[16] SINGH S L Michael I. Evaluating the Right Ventricle in Acute and Chronic Pulmonary Embolism: Current and Future Considerations[J/OL]. Seminars in Respiratory and Critical Care Medicine,2021,42(02):199-211.
[17] LI H, YU Y, WANG Y,等.Prognostic Risk Factors of 30-Day Death in Traumatic Lower Limb Fracture Patients with Acute Pulmonary Embolism:A Single-Center Retrospective Study[J/OL]. Canadian Respiratory Journal,2023,2023:1-9.
[18] Yin YJ, Chen YC, Xu L, Zhao XH, Song Yang. Relationship of lipoprotein-associated phospholipase A2(Lp-PLA2) and peri procedural myocardial injury in patients undergoing elective percutaneous coronary intervention.Int J Cardiol Heart Vasc. 2020;28:100541.Published2020May26.
[19] 王青松.血浆NT-proBNP cTnI D-D水平对急性肺栓塞发病风险的评估价值[J].河北医学,2020,26(10):1720-1723.
[20] Morillo R, Jiménez D, Bikdeli B, et al. Refinement of a modified simplified Pulmonary Embolism Severity Index for elderly patients with acute pulmonary embolism.Int J Cardiol. 2021;335:111-117.
[21] Asthana V, Sundararajan M, Ackah RL, et al. Heart failure education in the emergency department markedly reduces readmissions in un- and under-insured patients. Am J Emerg Med. 2018;36(12):2166-2171.
[22] Vagdatli E,Gounari E,Lazaridou E,Katsibourlia E,Tsiko poulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010 Jan;14(1):28-32. PMID: 20411056; PMCID:PMC2843567.
[23] KÖSE N, YILDIRIM T, AKIN F, 等. Prognostic role of NLR, PLR, and LMR in patients with pulmonary embolism[J/OL]. Bosni an Journal of Basic Medical.
[24] MEHMET BARAN KARATAS, GÖKTÜRK IPEK, TOLGA ONUK, 等.Assessment of Prognostic Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Patients with Pulmonary Embolism[J/OL].Acta Cardiologica Sinica,2016,32(3).
[25] NAUFFAL D, BALLESTER M, REYES R L,等.Influence of recent immobilization and recent surgery on mortality in patients with pulmonary embolism[J/OL].Journal of Thrombosis and Haemostasis,2012,10(9):1752-1760.
[26] LINDMAN B R, DÁVILA-ROMÁN V G,MANN D L,等.Cardiovas cular Phenotype in HFpEF Patients With or Without Diabetes [J/OL].Journal of the American College of Cardiology,2014,64 (6):541-549.
[27] OZSU S, ÇOŞAR A M, AKSOY H B, 等. Prognostic Value of Uric Acid for Pulmonary Thromboembolism[J/OL]. Respiratory Care,2017,62(8):1091-1096.
[28] NUMA S, HIRAI T, NAKAGAWA K,等.Hyperuricemia and Transesophageal Echocardiographic Thromboembolic Risk in Patients With Atrial Fibrillation at Clinically Low-Intermedia te Risk[J/OL]. Circulation Journal,2014,78(7):1600-1605.
[29] ZENG W, XU B, WANG X, 等. Identification of Prognostic Factors for Recurrence and Mortality in Patients With Acute Pulmonary Embolism[J/OL].The Heart Surgery Forum, 2022, 25(6):E812-E821.
[30] 王杭.急性肺栓塞患者的长期预后因素分析[D].蚌埠医学院,2023.
[31] Bai B, Ruan X, Zhang YL, et al.Zhonghua Yi Xue Za Zhi.2018;98(40):3240-3243.
[32] 刘翩,卓玉娟.慢性阻塞性肺疾病合并肺栓塞的短期预后及危险因素分析[J].中国当代医药,2019,26(09):18-21.
[33] Nielsen VG,Hafner DT,Steinbrenner EB.Tobacco smokeinduced hypercoagulation in human plasma: role of carbon monoxide.Blood Coagul Fibrinolysis.2013;24(4):405-410.
[34] Eckart A, Struja T,Kutz A,et al.Relationship of Nutrit ional Status, Inflammation, and Serum Albumin Levels During Acute Illness: A Prospective Study.Am J Med. 2020;133(6):713-722.e7.
[35] Zhang T,Xue PJ,Li YY, Peng M, Sun XF, Shi JH.Zhonghua Jie He He Hu XiZa Zhi.2022;45(6):539-545.
[36] POLYZOS S A,ANASTASILAKIS A D,EFSTATHIADOU Z A,等.Ir isin in metabolic diseases[J/OL].Endocrine,2018,59(2):260-274.
[37] Saghazadeh A, Hafizi S, Rezaei N. Inflammation in venous thromboembolism:Cause or consequence?.Int Immunopha rmacol.2015;28(1):655-665.
[38] YUAN S,BRUZELIUS M,DAMRAUER S M,等.Anti-inflammato ry diet and venous thromboembolism: Two prospective cohort studies[J/OL].Nutrition, Metabolism and Cardiovascular Diseas es,2021,31(10):2831-2838.
[39] Gurger M, Telo S, Yilmaz M, Atescelik M, Gul E, Goktekin MC. Diagnostic and Prognostic Relevance of Serum Irisin Level in Patients with Pulmonary Embolism.ClinLab.2021;67(3):10.7754 /Clin.Lab.2020.200608.
[40] 刘燕山,刘德智,张海生,等.鸢尾素、脂质运载蛋白-2与急性肺栓塞患者临床预后的关系[J].中国现代医药杂志,2024,26(02):15-19.
[2] 孙晓莉,樊兵权,杨芸.不同部位下肢深静脉血栓形成与急性肺栓塞后肺动脉高压病情的关系及对预后的影响[J].医学理论与实践,2024,37(06):945-947.
[3] KELLER K,HOBOHM L,EBNER M,等.Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany[J/OL].European Heart Journal,2020,41(4):522-529.
[4] Freund Y,Cohen-Aubart F, Bloom B.Acute Pulmonary Embolism:A Review. JAMA.2022;328(13):1336-1345.
[5] BUMROONGKIT C, DEESOMCHOK A,LIWSRISAKUN C等.Clinical Characteristics,Risk Factors, and Outcomes of Acute Pulmonary Embolism in Asian Population[J/OL].Journal of Clinical Medic ine,2022,11(23):6954.
[6] WENGER N, SEBASTIAN T,ENGELBERGER R P,等.Pulmonary embolism and deep vein thrombosis:Similar but different[J/OL]. Thrombosis Research,2021,206:88-98.
[7] Tian H, Zhang Y, Liu J, et al. Sex disparities of clinical manifestations in acute pulmonary embolism and predictive value for in-hospital mortality: Insights from CURES.Thromb Res.2024;243:109146.doi:10.1016/j.thromres.2024.109146.
[8] ZUIN M, RIGATELLI G, ZULIANI G,等.Seizures as the first clinical manifestation of acute pulmonary embolism: an under estimate issue in neurocritical care[J/OL].NeurologicalScien ces,2020,41(6):1427-1436.
[9] KHANDAIT H,HARKUT P,KHANDAIT V,等.Acute pulmonary em bolism: Diagnosis and management[J/OL]. Indian Heart Journal, 2023,75(5):335-342.DOI:10.1016/j.ihj.2023.05.007.
[10] 李博.急性肺血栓栓塞症的临床特征、预后评估和介入诊疗研究[D].吉林大学,2024.
[11] Escolar G,Díaz-Ricart M,Arellano-Rodrigo E. Betrixa ban: a direct oral inhibitor of activated factor X for the prophylaxis of venous thromboembolism in patients hospitalized for acute medical illness.Drugs Today(Barc).2017;53(8):423-434.
[12] 李建东,郭山峰,周涛,等.肺血栓栓塞症诊疗进展[J].中国临床研究,2025,38(02):169-172+185.
[13] Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the Euro pean Respiratory Society(ERS).Eur Heart J.2020;41(4):543-603.
[14] BioMed Research International. Retracted: Treatme nt of Acute Pulmonary Embolism: Update on Newer Pharmacolo gic and Interventional Strategies [retraction of: Biomed Res Int. 2014;2014:410341. doi: 10.1155/2014/410341.].Biomed Res Int.2019;2019:4217864.Published2019Aug22.
[15] Pruszczyk P,Klok FA,Kucher N,et al.Percutaneous treat ment options for acute pulmonary embolism: a clinical consen sus statement by the ESC Working Group on Pulmonary Circulat ion and Right Ventricular Function and the European Association of Percutaneous Cardiovascular Interventions.EuroInterventi on.2022;18(8):e623-e638.Published 2022 Oct7.
[16] SINGH S L Michael I. Evaluating the Right Ventricle in Acute and Chronic Pulmonary Embolism: Current and Future Considerations[J/OL]. Seminars in Respiratory and Critical Care Medicine,2021,42(02):199-211.
[17] LI H, YU Y, WANG Y,等.Prognostic Risk Factors of 30-Day Death in Traumatic Lower Limb Fracture Patients with Acute Pulmonary Embolism:A Single-Center Retrospective Study[J/OL]. Canadian Respiratory Journal,2023,2023:1-9.
[18] Yin YJ, Chen YC, Xu L, Zhao XH, Song Yang. Relationship of lipoprotein-associated phospholipase A2(Lp-PLA2) and peri procedural myocardial injury in patients undergoing elective percutaneous coronary intervention.Int J Cardiol Heart Vasc. 2020;28:100541.Published2020May26.
[19] 王青松.血浆NT-proBNP cTnI D-D水平对急性肺栓塞发病风险的评估价值[J].河北医学,2020,26(10):1720-1723.
[20] Morillo R, Jiménez D, Bikdeli B, et al. Refinement of a modified simplified Pulmonary Embolism Severity Index for elderly patients with acute pulmonary embolism.Int J Cardiol. 2021;335:111-117.
[21] Asthana V, Sundararajan M, Ackah RL, et al. Heart failure education in the emergency department markedly reduces readmissions in un- and under-insured patients. Am J Emerg Med. 2018;36(12):2166-2171.
[22] Vagdatli E,Gounari E,Lazaridou E,Katsibourlia E,Tsiko poulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010 Jan;14(1):28-32. PMID: 20411056; PMCID:PMC2843567.
[23] KÖSE N, YILDIRIM T, AKIN F, 等. Prognostic role of NLR, PLR, and LMR in patients with pulmonary embolism[J/OL]. Bosni an Journal of Basic Medical.
[24] MEHMET BARAN KARATAS, GÖKTÜRK IPEK, TOLGA ONUK, 等.Assessment of Prognostic Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Patients with Pulmonary Embolism[J/OL].Acta Cardiologica Sinica,2016,32(3).
[25] NAUFFAL D, BALLESTER M, REYES R L,等.Influence of recent immobilization and recent surgery on mortality in patients with pulmonary embolism[J/OL].Journal of Thrombosis and Haemostasis,2012,10(9):1752-1760.
[26] LINDMAN B R, DÁVILA-ROMÁN V G,MANN D L,等.Cardiovas cular Phenotype in HFpEF Patients With or Without Diabetes [J/OL].Journal of the American College of Cardiology,2014,64 (6):541-549.
[27] OZSU S, ÇOŞAR A M, AKSOY H B, 等. Prognostic Value of Uric Acid for Pulmonary Thromboembolism[J/OL]. Respiratory Care,2017,62(8):1091-1096.
[28] NUMA S, HIRAI T, NAKAGAWA K,等.Hyperuricemia and Transesophageal Echocardiographic Thromboembolic Risk in Patients With Atrial Fibrillation at Clinically Low-Intermedia te Risk[J/OL]. Circulation Journal,2014,78(7):1600-1605.
[29] ZENG W, XU B, WANG X, 等. Identification of Prognostic Factors for Recurrence and Mortality in Patients With Acute Pulmonary Embolism[J/OL].The Heart Surgery Forum, 2022, 25(6):E812-E821.
[30] 王杭.急性肺栓塞患者的长期预后因素分析[D].蚌埠医学院,2023.
[31] Bai B, Ruan X, Zhang YL, et al.Zhonghua Yi Xue Za Zhi.2018;98(40):3240-3243.
[32] 刘翩,卓玉娟.慢性阻塞性肺疾病合并肺栓塞的短期预后及危险因素分析[J].中国当代医药,2019,26(09):18-21.
[33] Nielsen VG,Hafner DT,Steinbrenner EB.Tobacco smokeinduced hypercoagulation in human plasma: role of carbon monoxide.Blood Coagul Fibrinolysis.2013;24(4):405-410.
[34] Eckart A, Struja T,Kutz A,et al.Relationship of Nutrit ional Status, Inflammation, and Serum Albumin Levels During Acute Illness: A Prospective Study.Am J Med. 2020;133(6):713-722.e7.
[35] Zhang T,Xue PJ,Li YY, Peng M, Sun XF, Shi JH.Zhonghua Jie He He Hu XiZa Zhi.2022;45(6):539-545.
[36] POLYZOS S A,ANASTASILAKIS A D,EFSTATHIADOU Z A,等.Ir isin in metabolic diseases[J/OL].Endocrine,2018,59(2):260-274.
[37] Saghazadeh A, Hafizi S, Rezaei N. Inflammation in venous thromboembolism:Cause or consequence?.Int Immunopha rmacol.2015;28(1):655-665.
[38] YUAN S,BRUZELIUS M,DAMRAUER S M,等.Anti-inflammato ry diet and venous thromboembolism: Two prospective cohort studies[J/OL].Nutrition, Metabolism and Cardiovascular Diseas es,2021,31(10):2831-2838.
[39] Gurger M, Telo S, Yilmaz M, Atescelik M, Gul E, Goktekin MC. Diagnostic and Prognostic Relevance of Serum Irisin Level in Patients with Pulmonary Embolism.ClinLab.2021;67(3):10.7754 /Clin.Lab.2020.200608.
[40] 刘燕山,刘德智,张海生,等.鸢尾素、脂质运载蛋白-2与急性肺栓塞患者临床预后的关系[J].中国现代医药杂志,2024,26(02):15-19.
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