Application Research Progress of Neuromodulation Technology in the Treatment of Freezing Gait in Parkinson's Disease

Journal: Journal of Clinical Medicine Research DOI: 10.32629/jcmr.v1i3.244

Guolin Shi, Ninghui Zhao, Tingting Wu

The Second Affiliated Hospital of Kunming Medical University

Abstract

Freezing gait is a common clinical symptom in patients with Parkinson's disease. It tends to get worse with the progress of the disease, causing the patients to fall easily, which is one of the important reasons for the loss of independent living ability. The treatment of frozen gait is very complicated, and drug treatment has no obvious effect. Neuromodulation technology is currently an effective method for clinical treatment of frozen gait in Parkinson's disease. This technology mainly uses implantable devices and non-implantable devices, and uses electrical or chemical methods to correct frozen gait, which helps to improve the quality of life of patients with Parkinson's disease. This article focuses on the application research of neuromodulation technology in the treatment of freezing gait in Parkinson's disease.

Keywords

Parkinson's disease, freezing gait, neuromodulation technology

References

[1] Peng Qiaojun, Wang Yufeng, Liu Xin, et al. Research progress in the characteristics and regulation of brain function network of non-motor symptoms in Parkinson’s disease. Chinese Journal of Neuroimmunology and Neurology. 2020; 27(5): 407-411.
[2] Wang Xianbin, Tang Hongyan, Li Xingtong, et al. The expression and role of Wnt signaling pathway and neurogenesis and neurodegeneration. Chinese Tissue Engineering Research. 2018; 22(28): 4587-4592.
[3] Zhang Hui, Ma Huiqing, Wang Xiaojuan. Ginkgo biloba extract exerts brain protection on Parkinson's disease rats by activating the Nrf2-ARE signaling pathway. Journal of Shenyang Pharmaceutical University. 2018; 35(8): 675- 679+695.
[4] Wu Xi, Wang Jiali, Qiu Yiqing, et al. Improving effect of stimulation parameter optimization on temporary non-motor symptoms induced by electrical stimulation after bilateral STN-DBS surgery in Parkinson’s disease. Chinese Journal of Clinical Medicine. 2017; 24(6): 845-852.
[5] Shi Kaixuan, Liu Xiaoli, Qiao Decai. The functional connection of the cortex-basal ganglia loop and the neuroplasticity mechanism of PD exercise prevention and treatment. Advances in Physiological Sciences. 2019; 50(1): 25-29.
[6] Lakkappa, Navya, Krishnamurthy, Praveen T., Pandareesh, MD, et al. Soluble epoxide hydrolase inhibitor, APAU, protects dopaminergic neurons against rotenone induced neurotoxicity: Implications for Parkinson's disease. Neurotoxicology. 2019; 70: 135 -145.
[7] Tosato, Marianna, Di Marco, Valerio.Metal Chelation Therapy and Parkinson's Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs. Biomolecules. 2019; 9(7): 269.
[8] Lin Chun, Meng Zhaoxiang, Jin Xing, et al. Clinical research and application of neuromodulation technology in the rehabilitation of Parkinson's disease. Chinese Journal of Physical Medicine and Rehabilitation. 2020; 42(3): 276-279.
[9] Zheng Yali, Bai Jiahe, Yu Yongpeng. The application progress of neuromodulation technology in the treatment of Parkinson’s disease frozen gait. Shandong Medicine. 2020; 60(7): 90-93.
[10] Lebel, Karina,Duval, Christian,Goubault, Etienne, et al. Parkinson's disease patients experiencing peak-dose dyskinesia redistribute involuntary movements throughout their body to improve motor control. Parkinsonism & Related Disorders. 2019; 64: 312 -314.

Copyright © 2021 Guolin Shi, Ninghui Zhao, Tingting Wu

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