干细胞联合中药方剂治疗心肌梗死的研究进展
Journal: Frontiers of Chinese Medicine Research DOI: 10.12238/fcmr.v4i2.5469
Abstract
心肌梗死(myocardial infarction,MI)是全世界范围内死亡率最高的疾病,也是致死率和致残率的首要因素之一。传统的治疗手段仅能改善症状而不能替换修复损伤的心肌细胞,这就迫切需要一种新型的治疗手段来修复改善心肌梗死。干细胞技术的发展以及干细胞特有的增殖分化能力使其成为再生医学极具潜力的工具。中药中的经典方剂“补阳还五汤”能够改善心肌梗死微环境,促进微小血管形成,同时具有抗炎,调节免疫等作用。综上,干细胞结合中药方剂共同用于心梗治疗应该会有较好的疗效。
Keywords
心肌梗塞；干细胞；中药方剂；补阳还五汤
Funding
(1)浙江省中医药科技计划青年人才基金项目,2019ZQ034；(2)浙江省自然科学基金青年基金项目,LQ19H180009。
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[7] Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663-76.
[8] Zhao M, Nakada Y, Wei Y, Bian W, Chu Y, Borovjagin AV, et al. Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction. Circulation. 2021;144:210-28.
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[12] Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991;9:641-50.
[13] Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stemcells.Science.1999;284:143-7.
[14] Lazarus HM, Koc ON, Devine SM, Curtin P, Maziarz RT, Holland HK, et al. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant. 2005;11:389-98.
[15] Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A. 2001;98:10344-9.
[16] Laflamme MA, Zbinden S, Epstein SE, Murry CE. Cellbased therapy for myocardial ischemia and infarction: path ophysiological mechanisms. Annu Rev Pathol.2007;2:307-39.
[17] Shen JF, Sugawara A, Yamashita J, Ogura H, Sato S. Dedifferentiated fat cells: an alternative source of adult multipotent cells from the adipose tissues. Int J Oral Sci. 2011;3:117-24.
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