基于知识图谱的解郁丸治疗失眠的作用机理研究
Journal: Frontiers of Chinese Medicine Research DOI: 10.12238/fcmr.v2i2.2942
Abstract
解郁丸是临床常用的抗抑郁方剂,在近年来的临床疗效研究中,被证明对失眠也具有一定的治疗作用,但具体机制并不清晰,本文将对其作用机制进行研究。利用Neo4j构建基于失眠和解郁丸作用机理的知识图谱；选择实体语法系统解析解郁丸治疗失眠的作用机制；对筛选获得的61个基因进行基因本体(GO)功能富集分析和基于京都基因与基因组百科全书(KEGG)通路富集分析,表明解郁丸主要是通过对昼夜睡眠周期、神经传导、消化系统、血液循环、免疫功能等生物过程的综合调节,达到治疗失眠的作用。研究结果指示,治疗失眠新药的研发可以从对神经系统、消化系统、内分泌系统的综合调节出发。
Keywords
失眠；解郁丸；实体语法系统；知识图谱
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[1] Ralitsa Todorova,Michaël Zugaro.
[2] Nina E.Fultz,Giorgio Bonmassar,
[3] Eti Ben Simon, Aubrey Rossi, Allison G.Harvey, et al. Overanxious and underslept.2020,4(1):100-110.
[4] Petrovic Dusan,Haba-Rubio José, de Mestral Vargas Carlos, et al. The contribution of sleep to social inequa
[5] Alexandros N V,Susan C,Duanping L,et al.Insomnia with objective short sleep duration is associated with type 2 diabetes.Diabetes Care,2009,32:1980
[6] Alexandros N V,Duanping L,Edward
[7] Anissa Kempf,Seoho M. Song,Cli
[8] 杨静娟,王绍臣,敖瑞.解郁丸治疗抑郁症临床研究[J].中国民间疗法,2015,23(07):53.
[9] 余洪敏.解郁丸联合米氮平片对焦虑性失眠(肝郁气滞、心神失养型)的疗效观察[D].河北医科大学,2014.
[2] Nina E.Fultz,Giorgio Bonmassar,
[3] Eti Ben Simon, Aubrey Rossi, Allison G.Harvey, et al. Overanxious and underslept.2020,4(1):100-110.
[4] Petrovic Dusan,Haba-Rubio José, de Mestral Vargas Carlos, et al. The contribution of sleep to social inequa
[5] Alexandros N V,Susan C,Duanping L,et al.Insomnia with objective short sleep duration is associated with type 2 diabetes.Diabetes Care,2009,32:1980
[6] Alexandros N V,Duanping L,Edward
[7] Anissa Kempf,Seoho M. Song,Cli
[8] 杨静娟,王绍臣,敖瑞.解郁丸治疗抑郁症临床研究[J].中国民间疗法,2015,23(07):53.
[9] 余洪敏.解郁丸联合米氮平片对焦虑性失眠(肝郁气滞、心神失养型)的疗效观察[D].河北医科大学,2014.
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