微小RNA与甲状腺乳头状癌的研究进展
Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v4i4.5455
Abstract
微小RNA(microRNA,miRNA)是一类存在于真核生物中,在进化上高度保守的内源性单链非编码RNA,属于小RNA。miRNA在许多生物代谢发展过程中充当重要角色。有相关研究表明,miRMA在恶性肿瘤中既可以作为原癌基因,也可以作为抑癌基因,调控着恶性肿瘤细胞增殖、分化、侵袭及凋亡等过程,为临床诊断及治疗恶性肿瘤提供了新方向,但目前对于miRNA的相关研究尚处于初步阶段。甲状腺癌(Thyroid Carcinoma,TC)是内分泌系统中常见的恶性肿瘤,其历年发病率呈上升趋势,目前已成为威胁人类生命健康的恶性疾病之一,其中绝大多数病理类型为甲状腺乳头状癌。本文拟就甲状腺乳头状癌相关miRNA的最新研究进展作一篇综述。
Keywords
微小RNA；甲状腺乳头状癌；研究进展
Funding
华北理工大学附属医院2020年博士科研启动项目(编号：bs2102)。
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[5] 查卫娜,刘阁玲,杨晓琳.MiRNAs在甲状腺癌中的研究进展[J].海南医学,2021,32(02):240-245.
[6] Mancikova V, Castelblanco E,Pineiro-Yanez E, et al. MicroRNA deep-sequencing reveals master regulators of folli cular and papillary thyroid tumors[J].Mod Pathol,2015,28(6):748-57.
[7] Kondrotienė A, Daukša A, Pamedytytė D, et al. Papil lary Thyroid Carcinoma Tissue miR-146b,-21,-221,-222,-181b Expression in Relation with Clinicopathological Features[J]. Diagnostics(Basel),2021,11(3):418.
[8] Wang Q, Shang J, Zhang Y, et al. MiR-451a restrains the growth and metastatic phenotypes of papillary thyroid carci noma cells via inhibiting ZEB1[J]. Biomed Pharmacother,2020, 127:109901.
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[11] Banerjee G,Singh D, Sinha AK. Plant cell cycle regul ators: Mitogen-activated protein kinase,a new regulating switch[J].Plant Sci, 2020,301:110660.
[12] Hong S, Yu S, Li J, et al. MiR-20b Displays TumorSuppressor Functions in Papillary Thyroid Carcinoma by Regu lating the MAPK/ERK Signaling Pathway[J]. Thyroid,2016,26 (12):1733-1743.
[13] Yu S, Cao S, Hong S, et al. miR-3619-3p promotes pap illary thyroid carcinoma progression via Wnt/β-catenin path way. Ann Transl Med[J],2019 7(22):643.
[14] Ren ZF, Du MF, Fu H, et al. MiR-200c promotes proli feration of papillary thyroid cancer cells via Wnt/β-catenin signaling pathway[J]. Eur Rev Med Pharmacol Sci,2020,24(10):5512-5518.
[15] Feng K, Liu Y, Xu LJ, et al. Long noncoding RNA PVT1 enhances the viability and invasion of papillary thyroid carcinoma cells by functioning as ceRNA of microRNA-30a thro ugh mediating expression of insulin like growth factor 1 receptor[J]. Biomed Pharmacother,2018,104:686-698.
[16] Liu L, Yang J, Zhu X, et al. Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer[J].FEBS J,2016,283(12):2326-2339.
[17] Zheng FB, Chen D, Ding YY, et al. Circular RNA circ_0103552 promotes the invasion and migration of thyroid carcinoma cells by sponging miR-127[J]. Eur Rev Med Pharma col Sci,2020,24(5):2572-2578.
[18] Zhang M, Wu W, Gao M, et al. MicroRNA-451 as a progn ostic marker for diagnosis and lymph node metastasis of papil lary thyroid carcinoma[J]. Cancer Biomark,2017,19(4):437- 445.
[19] Tsvetkov P, Coy S, Petrova B, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins[J].Science, 2022,375(6586):1254-1261.
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