弥漫内生型脑干胶质瘤的治疗现状

Journal: Basic Medical Theory Research DOI: 10.12238/bmtr.v4i4.5440

单绍波

北京航空航天大学生物医学工程学院

Abstract

弥漫内生型脑干胶质瘤(DIPG)是好发于儿童脑干部位的高度异质性脑肿瘤。此类肿瘤手术难度大且预后较差,常规化疗方案对肿瘤治疗无效,放疗同时无法延长患儿的有效生存期,因此患儿预后极差,有效生存期短。同时,由于脑干部位严密的血脑屏障的存在,很大程度上限制了药物治疗的效果。近年来随着对DIPG病理机制的深入研究以及新型给药方式的发展,针对DIPG的新兴疗法已取得了阶段性的进展。本文综述了包括DIPG的分子病理学改变、新型小分子药物以及新型给药方法等在内的DIPG研究现状,为提出改善DIPG患者预后治疗方案提供思路及参考。

Keywords

弥漫内生型脑干胶质瘤;病理学改变;药物递送

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